INT176522

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.65
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 71.32 Quite High
Inflammation 10 70.04 Quite High
rheumatoid arthritis 3 62.32 Quite High
metalloproteinase 1 26.92 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 67 100.00 Very High Very High Very High
Atherosclerosis 7 99.52 Very High Very High Very High
Renal Disease 27 98.72 Very High Very High Very High
Cardiovascular Disease 3 95.92 Very High Very High Very High
Coronary Artery Disease 36 93.52 High High
Ocular Toxicity (including Many Sub-types) 1 85.68 High High
Cancer 177 76.24 Quite High
Diabetes Complications 3 74.08 Quite High
INFLAMMATION 10 70.04 Quite High
Necrosis 4 68.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that the potential mislocalization of OPN and potential reduction in secreted OPN in these cells may lead to protein complexes, which alter signaling pathways and increase the migratory behavior of the cells.
Negative_regulation (reduction) of Localization (mislocalization) of OPN
1) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.41 Pain Relevance 0
We suggest that the potential mislocalization of OPN and potential reduction in secreted OPN in these cells may lead to protein complexes, which alter signaling pathways and increase the migratory behavior of the cells.
Negative_regulation (reduction) of Localization (secreted) of OPN
2) Confidence 0.37 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.40 Pain Relevance 0
Clinical relevance of OPN in diabetes
Negative_regulation (diabetes) of Localization (relevance) of OPN associated with diabetes mellitus
3) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.84 Pain Relevance 0.17

General Comments

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