INT176524

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 12.54
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
podocytes 2
muscle 1
skeletal muscle 1
platelet 1
nervous system 1
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 67 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
Nerve growth factor 136 99.32 Very High Very High Very High
sodium channel 3 98.00 Very High Very High Very High
Hyperalgesia 22 97.64 Very High Very High Very High
agonist 31 97.24 Very High Very High Very High
tetrodotoxin 3 97.00 Very High Very High Very High
Inflammatory response 35 96.24 Very High Very High Very High
fibrosis 5 95.48 Very High Very High Very High
rheumatoid arthritis 67 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenocarcinoma 61 99.50 Very High Very High Very High
Colitis 9 99.08 Very High Very High Very High
Acantholysis 65 99.04 Very High Very High Very High
Diabetes Mellitus 254 98.88 Very High Very High Very High
Bullous Skin Disease 304 98.54 Very High Very High Very High
Eosinophilia 1 97.72 Very High Very High Very High
Hyperalgesia 25 97.64 Very High Very High Very High
Pulmonary Disease 148 97.28 Very High Very High Very High
Aids-related Complex 142 97.12 Very High Very High Very High
Targeted Disruption 43 96.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are two of the major isoforms in the mature nervous system [31] and their activated forms are recognized by commercial p-p38 antibodies.
p38 Binding (recognized) of in nervous system
1) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.91 Pain Relevance 0.67
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration (up to 4 hours) resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
p38MAPK Binding (associated) of in podocytes
2) Confidence 0.38 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.50 Pain Relevance 0
The phosphorylated and total p38 MAPK protein levels from each sample were normalized to their respective ?
p38 MAPK protein Binding (normalized) of
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.24 Pain Relevance 0
We report that there is a p38-dependent TNF-?
p38 Binding (is) of
4) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.13 Pain Relevance 0.60
We demonstrate that NGF is an important factor to induce p38 activation in db/db mice.
p38 Binding (activation) of associated with nerve growth factor
5) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.40 Pain Relevance 1.25
This molecular mechanism could also occur in our model with elevated neuronal p38-mediated-TNF-?
p38 Binding (occur) of in neuronal
6) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.56 Pain Relevance 0.50
gene in skeletal muscle, providing additional mechanistic evidence supporting an obligatory role of p38?
p38 Binding (role) of in skeletal muscle
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0 Pain Relevance 0
Specifically relevant to endurance exercise-induced muscle adaptation, it has been shown that transgenic mice with forced exogenous expression of constitutively active p38 MAPK activator, MAPK kinase 6 (MKK6), have enhanced mitochondrial biogenesis [8], and functional interactions of the p38 MAPK/ATF2 and PKD/HDAC5/MEF2 signaling modules with the Pgc-1a promoter confer the transcriptional control [11], [12].
p38 MAPK Binding (interactions) of in muscle associated with targeted disruption
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775956 Disease Relevance 0.10 Pain Relevance 0
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
p38MAPK Binding (associated) of in podocytes
9) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.25 Pain Relevance 0
B) complex, platelet-derived growth factor BB (PDGF BB), p38 mitogen- activated protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) complex.
p38 Binding (complex) of in platelet
10) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.39 Pain Relevance 0.13
B complex, activator protein-1 (AP-1), p38 MAPK and Mek.
p38 MAPK Binding (complex) of
11) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.14 Pain Relevance 0.16
In addition, a recent study highlights the role of selectins and non-integrin collagen receptors in chemokine production and function through p38 mitogen-activated protein kinase and NF-?
p38 Binding (highlights) of associated with chemokine
12) Confidence 0.15 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.40 Pain Relevance 0.40
Interestingly, it has been demonstrated that p44/42 ERK/MAPK and p38 MAPK activity increases OPN expression.
p38 Binding (activity) of
13) Confidence 0.11 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.43 Pain Relevance 0
This was first shown using plakoglobin-deficient keratinocytes, which were resistant against PV-IgG-induced acantholysis and was further supported by the findings that inhibition of p38MAPK and activation of Rho A is sufficient to abolish PV-IgG and PF-IgG-induced skin blistering (Berkowitz et al. 2005, 2006, 2007b; Caldelari et al. 2001; Waschke et al. 2006).
p38MAPK Neg (inhibition) Binding (inhibition) of in skin associated with acantholysis and bullous skin disease
14) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.30 Pain Relevance 0
A recent study demonstrated the efficacy of p38?
p38 Binding (efficacy) of
15) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.23 Pain Relevance 0.37
These associations were absent in ductal epithelia from non-PDAC specimens except for an association of cytoplasmic and nuclear levels for p-p38 (?
p38 Neg (except) Binding (association) of associated with adenocarcinoma
16) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.66 Pain Relevance 0
This is mediated through CD74, the subsequent engagement of p38 MAPK, ERK, Src kinase, phospholipase A2 and PI3K pathways [104-108], and the binding of NF-?
p38 MAPK Binding (engagement) of
17) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.55 Pain Relevance 0.24
After microbial uptake, the action of p38 drives maturation of the phagosome [21], activates downstream kinases that result in the nuclear translocation of NF-?
p38 Binding (action) of
18) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.40 Pain Relevance 0.33
activity of the MAPKs p38 and the c-Jun N-terminal kinase (JNK), and of NF-?
p38 Binding (activity) of
19) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.80 Pain Relevance 0.19
Coupling between the opioid receptor and p38 MAPK (mitogen-activated protein kinase) was shown to be lost in the aged mouse heart, and phosphorylation of the downstream protein HSP27 (Heat shock protein 27) was reduced [52,53].


p38 MAPK Binding (Coupling) of in heart associated with shock and opioid receptor
20) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.17 Pain Relevance 0.37

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