INT176528

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 9.05
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Anatomy Link Frequency
plasma 4
lung 1
optic nerve 1
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 99.44 Very High Very High Very High
cytokine 56 94.40 High High
chemokine 8 75.52 Quite High
rheumatoid arthritis 16 66.20 Quite High
Thalamus 5 21.92 Low Low
imagery 10 8.76 Low Low
alcohol 7 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 335 100.00 Very High Very High Very High
Pneumonia 9 99.84 Very High Very High Very High
Bullous Skin Disease 60 99.80 Very High Very High Very High
Coronary Artery Disease 180 99.40 Very High Very High Very High
Targeted Disruption 111 99.36 Very High Very High Very High
Renal Disease 135 99.08 Very High Very High Very High
Melioidosis 57 98.64 Very High Very High Very High
Cancer 182 96.56 Very High Very High Very High
Infection 41 96.16 Very High Very High Very High
Renal Insufficiency 65 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-actin levels to determine the relative changes in levels of OPN protein.


Spec (determine) Regulation (changes) of OPN protein
1) Confidence 0.45 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.24 Pain Relevance 0
Compared with controls, diabetic patients had significantly higher OPN (P < 0.001), hsCRP (P < 0.001), and creatinine (P < 0.01) levels, were more likely to have moderate renal insufficiency (P < 0.01), and had a lower eGFR (P < 0.001; Table 2).
Regulation (controls) of OPN associated with diabetes mellitus and renal insufficiency
2) Confidence 0.39 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.10 Pain Relevance 0
The blots were scanned using a phosphorimager and normalized to 18s rRNA levels to determine the relative changes in OPN mRNA.


Spec (determine) Regulation (changes) of OPN
3) Confidence 0.24 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.23 Pain Relevance 0
To elucidate the relationship between OPN or N-half OPN and nephropathy or CAD in diabetes, T2DM patients were divided into two groups, those with higher than median plasma values of OPN (235.0 ng/mL) and N-half OPN (25.0 pmol/L) and those with median or lower plasma values of OPN and N-half OPN.
Regulation (values) of OPN in plasma associated with coronary artery disease, diabetes mellitus and renal disease
4) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.08 Pain Relevance 0
This was done because the distribution of plasma values of OPN and half-OPN is not normal.


Regulation (values) of OPN in plasma
5) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.00 Pain Relevance 0
To elucidate the relationship between OPN or N-half OPN and nephropathy or CAD in diabetes, T2DM patients were divided into two groups, those with higher than median plasma values of OPN (235.0 ng/mL) and N-half OPN (25.0 pmol/L) and those with median or lower plasma values of OPN and N-half OPN.
Regulation (values) of OPN in plasma associated with coronary artery disease, diabetes mellitus and renal disease
6) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.02 Pain Relevance 0
This was done because the distribution of plasma values of OPN and half-OPN is not normal.


Regulation (values) of OPN in plasma
7) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2988001 Disease Relevance 1.01 Pain Relevance 0
To study the influence of OPN on pulmonary inflammation during melioidosis, lung histology slides obtained 24 and 72 h after infection were semi-quantitatively scored as described in the Methods section.
Regulation (influence) of OPN in lung associated with inflammation, pneumonia, melioidosis and infection
8) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.78 Pain Relevance 0.74
In addition, either alterations in the subcellular distribution of armadillo proteins or the differential impact on other signaling pathways could also account for the observed differences in Dsg2's protective effect between ETA- or PF-treated Tg mice.
Regulation (account) of ETA associated with targeted disruption and bullous skin disease
9) Confidence 0.10 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.99 Pain Relevance 0
AP positive axons could be traced along the optic nerve/tract and targeted not only nuclei responsible for reflex light responses (the SCN, IGL, and OPN) but also those implicated in pattern vision.
Regulation (responsible) of OPN in optic nerve
10) Confidence 0.10 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2998442 Disease Relevance 0.20 Pain Relevance 0
Moreover, OPN is under the influence of both estrogen and vitamin D [16, 18].
Regulation (under) of OPN
11) Confidence 0.06 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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