INT176531

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 9.50
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SHC1) mitochondrion (SHC1) aging (SHC1)
plasma membrane (SHC1) nucleus (SHC1) cytoplasm (SHC1)
Anatomy Link Frequency
epithelial cells 1
endometrium 1
SHC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 864 99.84 Very High Very High Very High
pain pelvic 16 52.92 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Dismenorea 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 1104 99.84 Very High Very High Very High
Disease 92 98.36 Very High Very High Very High
Carcinoma 31 96.96 Very High Very High Very High
Breast Cancer 17 95.88 Very High Very High Very High
Aging 11 94.40 High High
Endometroid Carcinoma 8 92.80 High High
Atherosclerosis 6 88.96 High High
Cancer 112 84.12 Quite High
Targeted Disruption 9 84.04 Quite High
Coronary Artery Disease 23 77.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MAPK pathway is therefore constitutively activated in both human endometriosis and in the mouse endometriosis model, and the overexpression of SHC1 is an intriguing mechanism for the activation of this pathway in human endometriosis (Fig. 3).
Gene_expression (overexpression) of SHC1 associated with endometriosis
1) Confidence 0.67 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.12 Pain Relevance 0.40
PyV is capable of transforming cells by triggering signal transduction pathways that have been implicated as activated by erbB2, through interactions between its mT gene product and key cellular signaling proteins such as c-Src [14,15], Shc, and phosphatidylinositol 3-kinase (PI3-K) [16], which have all been implicated as important in human breast cancer.
Gene_expression (product) of Shc associated with breast cancer
2) Confidence 0.65 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 1.28 Pain Relevance 0
The human Shc locus (Src homologous and collagen) encodes three proteins with relative molecular masses of 46K (p46Shc), 52K (p52Shc) and 66K (p66Shc).
Gene_expression (locus) of Shc
3) Confidence 0.65 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.42 Pain Relevance 0
The transforming activity of SHC1 has been established [47], and its overexpression has been reported in neoplasias such as breast, gastric and hepatocelullar carcinomas [48-50].
Gene_expression (overexpression) of SHC1 associated with carcinoma
4) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.81 Pain Relevance 0.21
Although, the comparison of gene expression profiles between endometriosis and normal endometrium was done for the proliferative phase, AXL, SHC1, and ACTN4 (discussed below) were also overexpressed during secretory phase in ovarian endometriosis.
Gene_expression (overexpressed) of SHC1 in endometrium associated with endometriosis
5) Confidence 0.58 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.18 Pain Relevance 0.42
As overexpression of AXL and SHC1 theoretically activates both PI3K-Akt and MAPK pathways, dysregulation of these genes in human endometriosis may correspond to oncogenic activation of K-ras or biallelic losses of Pten in the mouse model of the disease.
Gene_expression (overexpression) of SHC1 associated with endometriosis and disease
6) Confidence 0.52 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.10 Pain Relevance 0.38
In human endometriosis, the PI3K-Akt and MAPK signaling pathways may be activated via overexpression of AXL and SHC1, respectively.
Gene_expression (overexpression) of SHC1 associated with endometriosis
7) Confidence 0.52 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2615013 Disease Relevance 0.93 Pain Relevance 0.34
Our data show that AXL and SHC1 are differentially expressed in endometriosis implicating the PI3K and MAPK pathways in this disease.
Gene_expression (expressed) of SHC1 associated with endometriosis and disease
8) Confidence 0.52 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.17 Pain Relevance 0.42
AXL, SHC1, and ACTN4, all shown to be overexpressed in endometriotic epithelial cells by SAGE, were selected for IHC validation.
Gene_expression (overexpressed) of SHC1 in epithelial cells associated with endometriosis
9) Confidence 0.52 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.71 Pain Relevance 0.26
Similar to what we observed for AXL, SHC1 was found consistently elevated in the studied endometriotic samples.
Gene_expression (observed) of SHC1 associated with endometriosis
10) Confidence 0.26 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.79 Pain Relevance 0.19

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