INT176540

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pik3cd) extracellular space (Spp1) signal transduction (Pik3cd)
extracellular region (Spp1) cell adhesion (Spp1) kinase activity (Pik3cd)
Pik3cd (Mus musculus)
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 67.04 Quite High
anesthesia 2 39.60 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 122 99.90 Very High Very High Very High
Cancer 176 95.40 Very High Very High Very High
Carcinoma 14 49.64 Quite Low
Targeted Disruption 14 47.84 Quite Low
Breast Cancer 34 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 22 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given this evidence, we conclude that PyV-mT induces a metastatic phenotype, at least in part, through the PI3-K-mediated transcriptional upregulation of the matrix protein OPN, although enforced expression of OPN in the lowly metastatic Db cells does not increase their metastasis rate.
PI3-K-mediated Positive_regulation (upregulation) of OPN associated with metastasis
1) Confidence 0.11 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.75 Pain Relevance 0.03
These data suggest a link between metastasis and phosphatidylinositol-3-kinase-mediated transcriptional upregulation of OPN, but additional phosphatidylinositol-3-kinase-regulated genes may be essential in precipitating the metastasis phenotype in the polyomavirus middle T model.



phosphatidylinositol-3-kinase Positive_regulation (upregulation) of OPN associated with metastasis
2) Confidence 0.11 Published 2004 Journal Breast Cancer Res Section Abstract Doc Link PMC400667 Disease Relevance 1.05 Pain Relevance 0

General Comments

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