INT176549

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Spp1) extracellular region (Spp1) cell adhesion (Spp1)
cytoplasm (Spp1)
Mtv7 (Mus musculus)
Spp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 1 67.04 Quite High
anesthesia 1 39.60 Quite Low
alcohol 3 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 61 96.20 Very High Very High Very High
Cancer 88 76.88 Quite High
Carcinoma 7 14.52 Low Low
Breast Cancer 17 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 11 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given this evidence, we conclude that PyV-mT induces a metastatic phenotype, at least in part, through the PI3-K-mediated transcriptional upregulation of the matrix protein OPN, although enforced expression of OPN in the lowly metastatic Db cells does not increase their metastasis rate.
PyV-mT Positive_regulation (upregulation) of OPN associated with metastasis
1) Confidence 0.26 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

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