INT176571

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.15
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
body 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 6 95.64 Very High Very High Very High
Potency 5 88.36 High High
Bioavailability 3 87.28 High High
cva 8 44.48 Quite Low
rheumatoid arthritis 21 31.84 Quite Low
palliative 1 7.04 Low Low
agonist 22 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 19 99.44 Very High Very High Very High
Breast Cancer 122 98.72 Very High Very High Very High
Anorexia 10 97.20 Very High Very High Very High
Cancer 71 97.04 Very High Very High Very High
Aneuploidy 1 95.96 Very High Very High Very High
Body Weight 1 94.56 High High
Mycobacterial Infection 49 90.68 High High
Reprotox - General 1 12 89.52 High High
Disease 16 79.76 Quite High
Postmenopausal Osteoporosis 9 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cytosol retention and inhibited transactivation of estrogen-response element
Negative_regulation (inhibited) of Positive_regulation (transactivation) of estrogen
1) Confidence 0.47 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.14 Pain Relevance 0
Because TCZ can suppress elevation of CRP and ESR, it is inadequate to evaluate its effectiveness by clinical scores.
Negative_regulation (suppress) of Positive_regulation (elevation) of ESR
2) Confidence 0.42 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2720589 Disease Relevance 1.00 Pain Relevance 0.05
Interestingly, the estrogen-stimulated induction of the cyclin D1 mRNA level was decreased by decursin only at the 3 hour timepoint.
Negative_regulation (decreased) of Positive_regulation (induction) of estrogen
3) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.07 Pain Relevance 0
Larger studies are needed to determine the clinical utility of ER?
Spec (determine) Negative_regulation (determine) of Spec (determine) Positive_regulation (utility) of ER
4) Confidence 0.28 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.83 Pain Relevance 0
with high affinity.46,47 In particular, its half-inhibition concentration for ER?
Negative_regulation (inhibition) of Positive_regulation (concentration) of ER
5) Confidence 0.06 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817938 Disease Relevance 0.32 Pain Relevance 0.13
sedimentation rate (ESR), and body temperature were measured
Negative_regulation (measured) of Positive_regulation (sedimentation) of ESR in body
6) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.78 Pain Relevance 0

General Comments

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