INT176586

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.64
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
agonist 32 85.04 High High
depression 3 55.24 Quite High
Pain 13 53.96 Quite High
Glutamate receptor 2 53.28 Quite High
cytokine 3 50.88 Quite High
cva 25 5.00 Very Low Very Low Very Low
Bioavailability 15 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
Nicotine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 45 99.74 Very High Very High Very High
Cancer 163 98.08 Very High Very High Very High
Syndrome 4 97.60 Very High Very High Very High
Breast Cancer 279 96.60 Very High Very High Very High
Cardiovascular Disease 2 96.04 Very High Very High Very High
Diabetes Mellitus 2 95.08 Very High Very High Very High
Uterine Fibroids 72 93.20 High High
Postmenopausal Osteoporosis 27 93.04 High High
Lifespan 2 84.88 Quite High
Death 17 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the action of decursin was probably not accounted for as an antagonist competitor for estrogen ligand binding to ER?.


Neg (not) Positive_regulation (accounted) of ER Binding (binding) of associated with antagonist
1) Confidence 0.41 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.05
This may suggest that the frequency of prolactin-related AEs associated with paliperidone ER therapy is underestimated.


Positive_regulation (frequency) of ER Binding (associated) of
2) Confidence 0.40 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0.18 Pain Relevance 0
Recent advances in translational research studies have highlighted the complexity of ER signaling, including differential roles for the ER?
Positive_regulation (highlighted) of ER Binding (complexity) of
3) Confidence 0.32 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.46 Pain Relevance 0
Measurement of estrogen receptor transcriptional activity by dual luciferase reporter assay
Positive_regulation (Measurement) of estrogen receptor Binding (activity) of
4) Confidence 0.27 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2949655 Disease Relevance 0.08 Pain Relevance 0
By contrast, genistein effectively bound to ER-?
Positive_regulation (effectively) of ER Binding (bound) of
5) Confidence 0.25 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.28 Pain Relevance 0.03
Physiological concentrations of genistein were similarly found to reverse the antagonistic effects of 4-hydroxytamoxifen on ER signalling pathways [53], promoting the binding of ER-?
Positive_regulation (promoting) of ER Binding (binding) of
6) Confidence 0.20 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.67 Pain Relevance 0.08
Work by Hayashi et al [9] in estrogen-dependent cancers provides an example where the constitutively activated MAPK signaling pathway in endometrial cancer cells might enhance the transcriptional activity of ER?
Spec (might) Positive_regulation (enhance) of ER Spec (might) Binding (activity) of associated with endometriosis (extended) and cancer
7) Confidence 0.16 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.88 Pain Relevance 0
An accumulation of misfolded proteins induces the dissociation of the ER-resident master chaperone regulator, BiP/GRP78 (Binding Immunoglobulin Protein/Glucose Response Protein 78), from three ER transmembrane sensor proteins: ATF6 (Activation of Transcription Factor 6), Ire1 (Inositol Requiring Enzyme 1?)
Positive_regulation (induces) of ER Binding (dissociation) of
8) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.93 Pain Relevance 0
Despite the remarkable progress made during the last two decades, the mechanism by which estrogen affects bone metabolism is complex and not fully elucidated.14–16 Estrogen acts through the binding and activation to two different estrogen receptors (ER), ER?
Positive_regulation (acts) of ER Binding (binding) of
9) Confidence 0.08 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817938 Disease Relevance 0.26 Pain Relevance 0.03
Despite the remarkable progress made during the last two decades, the mechanism by which estrogen affects bone metabolism is complex and not fully elucidated.14–16 Estrogen acts through the binding and activation to two different estrogen receptors (ER), ER?
Positive_regulation (acts) of ER Binding (binding) of
10) Confidence 0.08 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2817938 Disease Relevance 0.26 Pain Relevance 0.03
Similar changes in ER binding and arginase activity were observed in vaginal tissue extracts of ovariectomized rats.
Positive_regulation (changes) of ER Binding (binding) of
11) Confidence 0.06 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
This class of compounds includes chemically diverse molecules that lack the steroid structure of estrogens, but possess a tertiary structure that allows them to bind to ER?
Positive_regulation (allows) of ER Binding (bind) of
12) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899785 Disease Relevance 0.64 Pain Relevance 0.12

General Comments

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