INT176589

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.06
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 1 52.16 Quite High
imagery 4 32.80 Quite Low
headache 9 5.00 Very Low Very Low Very Low
pruritus 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 242 95.84 Very High Very High Very High
Repression 1 95.36 Very High Very High Very High
Gastrointestinal Stromal Tumor 9 94.88 High High
Chronic Myeloid Leukemia 1 94.40 High High
Recurrence 2 87.96 High High
Cancer 120 72.16 Quite High
Sarcoma 3 69.12 Quite High
Solid Tumor 10 68.00 Quite High
Disease 31 63.36 Quite High
Cv Unclassified Under Development 1 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib's effect is mediated by its ability to bind to the ATP-binding site on the tyrosine kinase, thus preventing its function.
Negative_regulation (preventing) of tyrosine kinase Binding (bind) of
1) Confidence 0.09 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2661077 Disease Relevance 0.95 Pain Relevance 0.05
some of the steric hindrances normally imposed on the tyrosine kinase activity,
Negative_regulation (imposed) of tyrosine kinase Binding (activity) of
2) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.14 Pain Relevance 0
interact with second messengers like calmodulin [10].

(3) Tyrosine Kinase DomainThe tyrosine kinase domain (TKD) is essential for the functional

Negative_regulation (messengers) of tyrosine kinase Binding (interact) of
3) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0
interact with second messengers like calmodulin [10].

(3) Tyrosine Kinase DomainThe tyrosine kinase domain (TKD) is essential for the functional

Negative_regulation (messengers) of Tyrosine Kinase Binding (interact) of
4) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0
Lapatinib binds to the ATP-binding site of tyrosine kinase, blocking phosphorylation and activation of the receptor.
Negative_regulation (blocking) of tyrosine kinase Binding (binds) of
5) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727787 Disease Relevance 0.48 Pain Relevance 0
The inhibition of tyrosine kinase activity by 5 ?
Negative_regulation (inhibition) of tyrosine kinase Binding (activity) of
6) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.49 Pain Relevance 0

General Comments

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