INT176589

Context Info Confidence 0.09 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.06 Pain Relevance 0.05

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK) cytoplasm (TXK)

TXK (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 1 52.16 imagery 4 32.80 headache 9 5.00 pruritus 3 5.00 antagonist 3 5.00 agonist 2 5.00 Central nervous system 1 5.00 depression 1 5.00 Angina 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 242 95.84 Repression 1 95.36 Gastrointestinal Stromal Tumor 9 94.88 Chronic Myeloid Leukemia 1 94.40 Recurrence 2 87.96 Cancer 120 72.16 Sarcoma 3 69.12 Solid Tumor 10 68.00 Disease 31 63.36 Cv Unclassified Under Development 1 58.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Imatinib's effect is mediated by its ability to bind to the ATP-binding site on the tyrosine kinase, thus preventing its function.

Negative_regulation (preventing) of tyrosine kinase Binding (bind) of

1) Confidence 0.09 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2661077 Disease Relevance 0.95 Pain Relevance 0.05

some of the steric hindrances normally imposed on the tyrosine kinase activity,

Negative_regulation (imposed) of tyrosine kinase Binding (activity) of

2) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.14 Pain Relevance 0

interact with second messengers like calmodulin [10]. (3) Tyrosine Kinase DomainThe tyrosine kinase domain (TKD) is essential for the functional

Negative_regulation (messengers) of tyrosine kinase Binding (interact) of

3) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0

interact with second messengers like calmodulin [10]. (3) Tyrosine Kinase DomainThe tyrosine kinase domain (TKD) is essential for the functional

Negative_regulation (messengers) of Tyrosine Kinase Binding (interact) of

4) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0

Lapatinib binds to the ATP-binding site of tyrosine kinase, blocking phosphorylation and activation of the receptor.

Negative_regulation (blocking) of tyrosine kinase Binding (binds) of

5) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727787 Disease Relevance 0.48 Pain Relevance 0

The inhibition of tyrosine kinase activity by 5 ?

Negative_regulation (inhibition) of tyrosine kinase Binding (activity) of

6) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.49 Pain Relevance 0

General Comments

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