INT176593

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 80.00 Quite High
Inflammation 54 50.00 Quite Low
cytokine 27 26.92 Quite Low
metalloproteinase 2 14.56 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 54 99.08 Very High Very High Very High
Myeloid Leukemia 2 87.80 High High
Apoptosis 19 73.12 Quite High
Leukemia 2 69.16 Quite High
Cancer 43 60.28 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Death 10 40.00 Quite Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Persistently active Rho family and Rac1 results in the activation of JAKs and subsequent tyrosine phosphorylation and activation of STAT3 [74].
Positive_regulation (activation) of Gene_expression (results) of Rac1
1) Confidence 0.17 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.35 Pain Relevance 0
-expressing breast cancer cells with resveratrol resulted in a 23-fold increase in p21WAF1 gene expression, as determined by cDNA microarray analysis.
Positive_regulation (increase) of Gene_expression (expression) of p21WAF1 associated with breast cancer
2) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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