INT176594

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.65
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRA1) cell proliferation (SRA1) nucleus (SRA1)
DNA binding (SRA1) cytoplasm (SRA1)
Anatomy Link Frequency
sputum 1
macrophage 1
pore 1
endometrium 1
SRA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 345 99.52 Very High Very High Very High
cytokine 87 91.56 High High
Inflammation 89 91.16 High High
endometriosis 36 89.44 High High
Somatostatin 1 62.24 Quite High
depression 1 53.32 Quite High
Pain 12 52.04 Quite High
carbamazepine 2 46.88 Quite Low
withdrawal 3 46.24 Quite Low
anesthesia 12 39.48 Quite Low
Disease Link Frequency Relevance Heat
Adult T-cell Leukemia-lymphoma 17 99.58 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 345 99.52 Very High Very High Very High
Pulmonary Disease 320 99.24 Very High Very High Very High
Hypersensitivity 3 99.22 Very High Very High Very High
Hypercalcemia 16 98.92 Very High Very High Very High
Polycystic Ovary Syndrome 18 98.70 Very High Very High Very High
Nicotine Addiction 45 98.56 Very High Very High Very High
Hemorrhage 3 97.78 Very High Very High Very High
Disease 240 97.48 Very High Very High Very High
Cancer 63 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It had been shown that a gene called serum resistance-associated (SRA) gene is only expressed in the resistant clone of T. b. rhodesiense and not in the sensitive clone of the same parasite [91–93].
Neg (not) Gene_expression (expressed) of SRA
1) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.09 Pain Relevance 0
The expression of SRA by T. b. rhodesiense is not a permanent phenomenon as it looses the resistance to NHS in the absence of the trypanolytic factor of the human serum, for example, after several passage in mice [95] or the T. b rhodesiense which are found in nonprimate animals [96].
Gene_expression (expression) of SRA
2) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.08 Pain Relevance 0
In case of T. rhodesiense the resistance to the trypanolytic capacity of APOL-1 is due to the expression of serum resistance-associated (SRA) protein [94] which neutralizes APOL1 through the interaction with the C-terminal of this lipoprotein.
Gene_expression (expression) of SRA
3) Confidence 0.31 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.47 Pain Relevance 0
As in the VSGs, the SRA contains the N-terminal ?
Gene_expression (contains) of SRA
4) Confidence 0.30 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.06 Pain Relevance 0
The SRA protein expressed by T. b. rhodesiense interacts with the C-terminal domain of APOL1 in the endosomes and/or lysosomes which prevents the APOL1 being able to form the pore, and as such makes the parasite resistant to the APOL1/ NHS.


5.

Gene_expression (expressed) of SRA protein in pore
5) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.42 Pain Relevance 0
In case of T. rhodesiense the resistance to the trypanolytic capacity of APOL-1 is due to the expression of serum resistance-associated (SRA) protein [94] which neutralizes APOL1 through the interaction with the C-terminal of this lipoprotein.
Gene_expression (neutralizes) of SRA
6) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.46 Pain Relevance 0
The analysis of complexes shows that this system forms a single complex having a ?
Gene_expression (analysis) of complexes
7) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
Thus, the search for complexes of maximum ?
Gene_expression (search) of complexes
8) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
to the positively acting steroid receptor coactivator (SRC)-1.
Gene_expression (acting) of steroid receptor coactivator
9) Confidence 0.06 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.65 Pain Relevance 0.08
New therapies targeting the Receptor Activator of NF-?
Gene_expression (targeting) of Receptor Activator
10) Confidence 0.05 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954972 Disease Relevance 1.43 Pain Relevance 0
expression can result in a reduced activity of cyclin/CDK complexes which
Gene_expression (/) of complexes
11) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0
ATLL patients also often express receptor activator of NF-kB ligand (RANKL), which cooperates with macrophage colony-stimulating-factor to stimulate haematopoietic precursors into osteoclasts.
Gene_expression (express) of receptor activator in macrophage associated with adult t-cell leukemia-lymphoma
12) Confidence 0.01 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.34 Pain Relevance 0.17
Supplementary administration of a SPRM improved bleeding patterns in women using progestogen-only pill (POP) regimen50 or subdermal contraceptive implants releasing LNG (Norplant).51 The improvement in bleeding pattern could be either by a direct effect of antiprogestin on the endometrium, as suggested by the effect on steroid receptor expression, or by inducing ovulation.52 An increased ovulation rate may jeopardize contraception, Therefore, theorectically, concomitant use of UPA with LNG EC is not recommended.
Gene_expression (expression) of steroid receptor in endometrium associated with hemorrhage
13) Confidence 0.01 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.33 Pain Relevance 0
We recently demonstrated that the reduction in endometrial beta 3 integrin expression in PCOS was associated with elevated expression of ER-alpha and an over-expression of steroid receptor coactivators [20].
Gene_expression (expression) of steroid receptor associated with polycystic ovary syndrome
14) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.55 Pain Relevance 0.09
In this case, however, the failure to down-regulate ER-alpha may be due to a hypersensitivity to estrogen, as evidenced by the over-expression of steroid receptor coactivators and ER-alpha itself [20].
Gene_expression (expression) of steroid receptor associated with hypersensitivity
15) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0.62 Pain Relevance 0.13
It has been shown that Hb complexes, detected by 2-DE of purified human globin chains, are formed through disulfide bonds [30].
Gene_expression (detected) of complexes
16) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.40 Pain Relevance 0.16
Hb complexes or monomers could barely be detected in the BALF or sputum supernatants by Western analysis.
Gene_expression (detected) of complexes in sputum
17) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.51 Pain Relevance 0.09
The levels of Hb complexes declined only in IPF for reasons that remain unclear.
Gene_expression (levels) of complexes associated with fibrosis
18) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.56 Pain Relevance 0.13
complexes and also Hb monomers in the tissues, were not clearly detectable in the secretions.


Neg (not) Gene_expression (detectable) of complexes
19) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.52 Pain Relevance 0.10
Since Hb complexes, detected by 2-DE, are known to be formed through disulfide bonds [30], Hb?
Gene_expression (detected) of complexes
20) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.01 Pain Relevance 0.20

General Comments

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