INT1766

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 6.54
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYCARD) signal transduction (PYCARD) intracellular (PYCARD)
cytoplasm (PYCARD)
Anatomy Link Frequency
liver 2
PPC 1
ASC 1
Brain 1
cortex 1
PYCARD (Homo sapiens)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 1601 100.00 Very High Very High Very High
depression 124 100.00 Very High Very High Very High
antidepressant 72 99.98 Very High Very High Very High
Catecholamine 21 99.40 Very High Very High Very High
Neuropathic pain 23 99.12 Very High Very High Very High
Osteoarthritis 22 98.44 Very High Very High Very High
Dopamine 93 98.36 Very High Very High Very High
Pain 106 98.14 Very High Very High Very High
Bioavailability 26 91.92 High High
Central nervous system 12 90.08 High High
Disease Link Frequency Relevance Heat
Depression 126 100.00 Very High Very High Very High
Disease 158 99.92 Very High Very High Very High
Stroke 17 99.44 Very High Very High Very High
Neuropathic Pain 32 99.12 Very High Very High Very High
Osteoarthritis 22 98.44 Very High Very High Very High
Cerebral Palsy 20 98.20 Very High Very High Very High
Cognitive Disorder 97 96.12 Very High Very High Very High
Syndrome 14 94.80 High High
Anxiety Disorder 45 92.88 High High
Congenital Anomalies 10 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cowey et al. [31] found that online rTMS of both V5 and V2/V3 impaired direction of coherent motion discrimination but not detection of coherent motion.
Negative_regulation (impaired) of rTMS
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.04
Importantly, this suggestion was supported by a high degree of spatial overlap between the aforementioned network of TMS-induced BOLD signal decreases and an fMRI functional connectivity map that was referenced to right PPC and specific to the visuospatial judgment task [21].
Negative_regulation (decreases) of TMS-induced in PPC associated with transcranial magnetic stimulation
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0.07 Pain Relevance 0.45
Therefore, this study provides indirect evidence (constituted by our offline TMS over MFG results) for the functional relevance of remote neural effects of TMS (the decrease of MFG activation found by Sack et al. [21] during TMS over PPC).
Negative_regulation (effects) of TMS in neural associated with transcranial magnetic stimulation
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.47
Thus, in stimulating MFG in different participants, the effect of TMS was dependent on an interaction between the individual cortical excitability and the distance of the MFG cluster from the TMS coil (the depth of the functional cluster).
Negative_regulation (effect) of TMS associated with transcranial magnetic stimulation
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.28
For some participants, this may have led to no, or a lower, effect of TMS in TW1 (and perhaps TW2) over MFG, increasing overall variability.
Neg (no) Negative_regulation (effect) of TMS associated with transcranial magnetic stimulation
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.30
Paired pulse TMS (ppTMS)
Negative_regulation (Paired) of ppTMS associated with transcranial magnetic stimulation
6) Confidence 0.36 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.54 Pain Relevance 0.27
During TMS or rTMS, functioning of the stimulated cortical area can be temporarily disrupted, creating in effect a “virtual lesion”.
Negative_regulation (disrupted) of rTMS associated with transcranial magnetic stimulation
7) Confidence 0.36 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.66 Pain Relevance 0.15
During TMS or rTMS, functioning of the stimulated cortical area can be temporarily disrupted, creating in effect a “virtual lesion”.
Negative_regulation (disrupted) of TMS associated with transcranial magnetic stimulation
8) Confidence 0.36 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671781 Disease Relevance 0.66 Pain Relevance 0.16
In accordance with this idea that our high-intensity TMS might induce a pedestal-like effect, we found in Experiment 2 that TMS now reduced rather than facilitated subjects’ somatosensory performance.
Negative_regulation (reduced) of TMS associated with transcranial magnetic stimulation
9) Confidence 0.35 Published 2010 Journal Neuropsychologia Section Body Doc Link PMC2956832 Disease Relevance 0 Pain Relevance 0.31
Instead of getting primed for the recognition of altered intracellular structures potentially generated as a consequence of UV irradiation, downregulation of ASC, Cardinal, and caspase-1 might prevent the triggering of the innate immunity system by limiting the available adaptor and enzyme molecules.
Negative_regulation (downregulation) of ASC
10) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.37 Pain Relevance 0
Five rTMS blocks were delivered, each block separated by a 5-minute interval.
Negative_regulation (blocks) of rTMS
11) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725302 Disease Relevance 0.05 Pain Relevance 0.13
Instead, we investigated whether Standard TMS could be distinguished from Reversed TMS using the Circ coil.
Negative_regulation (distinguished) of TMS associated with transcranial magnetic stimulation
12) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.75
The results thus far show that EMF amplitude of Sham compared to Standard or Reversed TMS is significantly reduced.
Negative_regulation (reduced) of TMS associated with transcranial magnetic stimulation
13) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.40
When Reversed was delivered after Standard TMS (or Standard after Reversed), similarly there was no significant effect of the 1st pulse on the 2nd (Fig8: t(38)?
Negative_regulation (delivered) of TMS associated with transcranial magnetic stimulation
14) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271126 Disease Relevance 0 Pain Relevance 0.31
The ability of ASC to respond to exogenous PGE2 stimulation of cAMP synthesis is inhibited or stimulated by factors that increase or decrease PGE2 levels, respectively, in the cultures.
Negative_regulation (inhibited) of ASC in ASC
15) Confidence 0.28 Published 1979 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 231404 Disease Relevance 0.35 Pain Relevance 0.21
Importantly, during post control (PC) contractions after the removal of both IP and Asc, both conditions return to the control (C) force, indicating that neither application damaged the tissues.
Negative_regulation (removal) of Asc
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
Care was taken to deliver the TMS pulse during the grasping phase or, in trials without observation tasks, after 3–5 seconds of odorant stimulation.
Negative_regulation (deliver) of TMS associated with transcranial magnetic stimulation
17) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253499 Disease Relevance 0.05 Pain Relevance 0.05
Brain reorganisation has been demonstrated using TMS and fMRI following intensive UL training in adults after chronic stroke[49].
Negative_regulation (using) of TMS in Brain associated with stroke
18) Confidence 0.10 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2832893 Disease Relevance 0.61 Pain Relevance 0.04
On the other hand, the lack of motor cortex disinhibition in patients with painful osteoarthritis as a chronic non-neuropathic pain condition might allow predicting a therapy failure of rTMS applied to the motor cortex in these patients.


Negative_regulation (failure) of rTMS in cortex associated with pain, neuropathic pain and osteoarthritis
19) Confidence 0.08 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2898830 Disease Relevance 1.32 Pain Relevance 1.20
In addition, it is of interest to note that Jorge et al (2004) reported that reduction of depression symptoms in rTMS treated post stroke patients was not influenced by the patient’s age or type or location of ischemic strokes.
Negative_regulation (reduction) of rTMS associated with depression and stroke
20) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656335 Disease Relevance 0.35 Pain Relevance 0.16

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