INT176606

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.87
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
lymphocytes 2
bands 2
macrophages 1
Th2 cells 1
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 126 96.08 Very High Very High Very High
Inflammation 143 86.88 High High
agonist 5 80.16 Quite High
chemokine 13 67.92 Quite High
fibrosis 1 35.60 Quite Low
Crohn's disease 34 34.40 Quite Low
corticosteroid 29 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
pruritus 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 42 99.68 Very High Very High Very High
Lymphatic System Cancer 104 98.04 Very High Very High Very High
Syndrome 62 95.88 Very High Very High Very High
Atherosclerosis 67 94.92 High High
Occupational Lung Diseases 8 91.92 High High
Sprains And Strains 38 89.72 High High
Francisella Infection 58 89.56 High High
Disease 117 89.28 High High
Infection 64 88.64 High High
Hypersensitivity 26 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the 3 experimental lanes, there were no detectable phosphorylated STAT-6 bands.
Neg (no) Gene_expression (detectable) of STAT-6 in bands
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
In negative control lanes, no bands were detected for phosphorylated STAT-6 (Figure 1).
Neg (no) Gene_expression (detected) of STAT-6 in bands
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
Another study, demonstrated different gene expression profiles including increased expression of STAT6, IL-4, IL-13 in allergen-stimulated Th2 cells [6].
Gene_expression (expression) of STAT6 in Th2 cells
3) Confidence 0.55 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 1.06 Pain Relevance 0.08
, STAT1, pSTAT1, STAT6, and pSTAT6 production in RAW264.7 cells.


1.

Gene_expression (production) of STAT6
4) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2840610 Disease Relevance 0.60 Pain Relevance 0.04
, STAT1, pSTAT1, STAT6, and pSTAT6 production in RAW264.7 cells.


1.

Gene_expression (production) of pSTAT6
5) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2840610 Disease Relevance 0.60 Pain Relevance 0.04
Similarly, the expression of IL-4 and STAT6 decreased more in the DSS + IO (D) than the DSS (B) group.
Gene_expression (expression) of STAT6
6) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 0.46 Pain Relevance 0.10
IL-4/STAT6 signaling could not suppress twist1 expression in residual IFN-?
Gene_expression (signaling) of STAT6
7) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
and STAT6 signaling, [51] and in addition, IL-4 treatment of macrophages up-regulates PPAR?
Gene_expression (signaling) of STAT6 in macrophages
8) Confidence 0.36 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.15 Pain Relevance 0.38
Vorinostat at concentrations capable of producing apoptosis, decreased the expression of Stat6 and phosphor-Stat-6 (but not Stat3 and phosphor-Stat3) were seen in CTCL cell lines and peripheral blood lymphocytes from SS patients (Duvic and Zhang 2006).


Gene_expression (expression) of Stat6 in lymphocytes associated with lymphatic system cancer, syndrome and apoptosis
9) Confidence 0.21 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.05 Pain Relevance 0
Vorinostat at concentrations capable of producing apoptosis, decreased the expression of Stat6 and phosphor-Stat-6 (but not Stat3 and phosphor-Stat3) were seen in CTCL cell lines and peripheral blood lymphocytes from SS patients (Duvic and Zhang 2006).


Gene_expression (expression) of phosphor-Stat-6 in lymphocytes associated with lymphatic system cancer, syndrome and apoptosis
10) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721288 Disease Relevance 1.06 Pain Relevance 0
deletion of STAT6, a transcription factor required for the activation of Th2
Gene_expression (deletion) of STAT6
11) Confidence 0.17 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.89 Pain Relevance 0.14

General Comments

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