INT176607

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 19.51
Pain Relevance 11.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cx3cl1) extracellular region (Cx3cl1) cell adhesion (Cx3cl1)
plasma membrane (Cx3cl1) cytoplasm (Cx3cl1)
Anatomy Link Frequency
endothelial cells 4
tears 3
macrophage 2
fibroblasts 2
eyes 2
Cx3cl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 880 100.00 Very High Very High Very High
chemokine 582 100.00 Very High Very High Very High
ischemia 278 100.00 Very High Very High Very High
antagonist 101 100.00 Very High Very High Very High
rheumatoid arthritis 82 99.84 Very High Very High Very High
Inflammatory response 105 98.12 Very High Very High Very High
Inflammation 859 97.76 Very High Very High Very High
IPN 10 90.56 High High
psoriasis 13 85.20 High High
Lasting pain 11 83.80 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 112 100.00 Very High Very High Very High
Cv General 4 Under Development 22 100.00 Very High Very High Very High
Injury 1344 99.72 Very High Very High Very High
Vasculitis 12 99.72 Very High Very High Very High
Sicca Syndrome 70 99.64 Very High Very High Very High
Asthma 109 99.56 Very High Very High Very High
Eye Disease 650 99.48 Very High Very High Very High
Cystitis 70 99.08 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 1 99.08 Very High Very High Very High
Respiratory Syncytial Virus 100 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 15 molecules analyzed, EGF, fractalkine/CX3CL1, IL-1Ra, and IP-10/CXCL10 were detected in all samples (Figure 1).
Gene_expression (detected) of CX3CL1
1) Confidence 0.75 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.68 Pain Relevance 0.25
Soluble fractalkine/CX3CL1 is a potent chemoattractant for CX3CR1+ leukocytes.
Gene_expression (leukocytes) of CX3CL1 in leukocytes
2) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.60 Pain Relevance 0.27
There was a significant positive association with age for fractalkine/CX3CL1 levels in OS (p=0.0019) and borderline significant in OD (p=0.0573; Figure 3); IL-8/CXCL8 levels in both eyes had the same tendency, almost reaching significance for OS (p=0.09).
Gene_expression (levels) of CX3CL1 in eyes
3) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.35 Pain Relevance 0.39
In general, there was an inverse relationship between the levels of IL-Ra, IL-6, IL-8/CXCL8 and fractalkine/CX3CL1 and the Schirmer test, lysozyme, and TBUT values.
Gene_expression (levels) of fractalkine associated with sicca syndrome and antagonist
4) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.50 Pain Relevance 0.26
Our study revealed that tears from mild-to-moderate DED patients have significantly increased levels of EGF, fractalkine/CX3CL1, IL-1Ra, IP10/CXCL-10, IL-8/CXCL8, and VEGF.
Gene_expression (levels) of CX3CL1 in tears associated with eye disease
5) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.30 Pain Relevance 0.40
EGF, fractalkine/CX3CL1, IL-1Ra, IP-10/CXCL10, and VEGF levels in tears of DED patients were compared to control tear levels determined in 9 healthy subjects (18 eyes).
Gene_expression (levels) of CX3CL1 in eyes associated with eye disease
6) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.49 Pain Relevance 0.37
In general, there was an inverse relationship between the levels of IL-Ra, IL-6, IL-8/CXCL8 and fractalkine/CX3CL1 and the Schirmer test, lysozyme, and TBUT values.
Gene_expression (levels) of CX3CL1 associated with sicca syndrome and antagonist
7) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.50 Pain Relevance 0.26
Fractalkine/CX3CL1 has also been detected in RA synovial tissues [19].
Gene_expression (detected) of CX3C associated with rheumatoid arthritis
8) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.77 Pain Relevance 0.71
Recently, CX3CR1 and CX3CL1 expression by cells of the urinary bladder have been shown to be enhanced following CYP-induced cystitis [18].
Gene_expression (expression) of CX3CL1 in urinary bladder associated with cystitis
9) Confidence 0.56 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.62 Pain Relevance 0.67
CX3CL1 is an example of a molecule expressed and secreted by neurons that regulates the microglia phenotype (Ransohoff and Perry, 2009).
Gene_expression (expressed) of CX3CL1 in neurons
10) Confidence 0.44 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.28 Pain Relevance 0
Expression of fractalkine enables bypassing of the first 2 steps of the adhesion cascade (i.e., rolling and triggering) and mediates cell adhesion between circulating leukocytes and endothelial cells as well as extravasation of these cells.
Gene_expression (Expression) of fractalkine in leukocytes associated with adhesions
11) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.73 Pain Relevance 0.50
Proinflammatory cytokines increase expression of the CX3C chemokine, fractalkine, on injured endothelial cells.
Gene_expression (expression) of CX3C in endothelial cells associated with chemokine and cytokine
12) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.66 Pain Relevance 0.65
Proinflammatory cytokines increase expression of the CX3C chemokine, fractalkine, on injured endothelial cells.
Gene_expression (expression) of fractalkine in endothelial cells associated with chemokine and cytokine
13) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.72 Pain Relevance 0.65
Fractalkine expression is increased in the endothelium of large blood vessels, capillaries, and glomeruli in ischemic AKI and fractalkine receptor inhibition is protective against ischemic AKI [60].
Gene_expression (expression) of Fractalkine in blood vessels associated with injury
14) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.90 Pain Relevance 0.28
Fractalkine expression is increased in patients with renal tubulointerstitial inflammation with the strongest expression localized to vascular sites near to macrophage inflammation [59].
Gene_expression (expression) of Fractalkine in macrophage associated with inflammation
15) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.83 Pain Relevance 0.33
Fractalkine expression is also increased in the blood vessels in mouse kidneys exposed to cisplatin [61].
Gene_expression (expression) of Fractalkine in blood vessels
16) Confidence 0.38 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.22
Fractalkine is a membrane-bound chemokine expressed by endothelial cells of lungs and is possibly involved in asthma pathogenesis [34].
Gene_expression (expressed) of Fractalkine in endothelial cells associated with asthma and chemokine
17) Confidence 0.36 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.71 Pain Relevance 0.15
Fractalkine has a mucin-like stalk that extends the chemokine domain away from the endothelial cell surface enabling presentation of the CX3C-chemokine domain to leukocytes.
Gene_expression (presentation) of CX3C in stalk associated with chemokine
18) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.67 Pain Relevance 0.51
We performed correlation analyses between cytokine/chemokine levels and all signs and symptoms for the seven molecules detected in more than 50% of DED patients (Figure 2): EGF, fractalkine/CX3CL1, IL-1Ra, IL-8/CXCL8, IP-10/CXCL10, VEGF, and IL-6.
Gene_expression (fractalkine) of CX3CL1 associated with chemokine, eye disease and cytokine
19) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.40 Pain Relevance 0.42
EGF, fractalkine/CX3CL1, IL-1Ra, IP-10/CXCL10, and VEGF levels were the only molecules that were determined using the same reagents for both DED and control tears.
Gene_expression (levels) of CX3CL1 in tears associated with eye disease
20) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.29 Pain Relevance 0.37

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