INT176614

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 16.20
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
lung 6
plasma 4
brain 4
cerebellum 4
spleen 2
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 589 100.00 Very High Very High Very High
cytokine 229 100.00 Very High Very High Very High
Inflammation 310 99.16 Very High Very High Very High
Inflammatory response 53 95.08 Very High Very High Very High
Central nervous system 112 91.40 High High
Inflammatory mediators 2 90.08 High High
Demyelination 24 63.44 Quite High
cva 20 56.32 Quite High
fibrosis 25 54.24 Quite High
Spinal cord 16 31.92 Quite Low
Disease Link Frequency Relevance Heat
Infection 562 99.80 Very High Very High Very High
Sprains And Strains 84 99.48 Very High Very High Very High
INFLAMMATION 355 99.16 Very High Very High Very High
Pneumococcal Infection 10 98.96 Very High Very High Very High
Amyloid Plaque 7 98.76 Very High Very High Very High
Malaria 480 98.48 Very High Very High Very High
Chlamydia Infection 211 98.20 Very High Very High Very High
Togavirus Infection 75 96.48 Very High Very High Very High
Disease 166 96.12 Very High Very High Very High
Multiple Sclerosis 158 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic increase in RANTES protein expression began four days after P. yoelii 17XL infection, until peak parasitaemia at day eight with about three-fold upregulation in infected plasma compared with control [Figure 4B].


Positive_regulation (increase) of Gene_expression (expression) of RANTES in plasma associated with infection
1) Confidence 0.59 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.48 Pain Relevance 0.03
The results of this study demonstrate that the increase in production of RANTES follows the course of P. yoelii 17XL malaria infection, thus RANTES and its receptors CCR1, CCR3 and CCR5 were detected at their highest levels at day six and day eight post-infection.
Positive_regulation (increase) of Gene_expression (production) of RANTES associated with malaria and infection
2) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.02 Pain Relevance 0.20
Thus, the increase in RANTES production correlated with the increase in parasitaemia and pathological changes observed in the P. yoelii 17XL-infected mice in this investigation.
Positive_regulation (increase) of Gene_expression (production) of RANTES
3) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.72 Pain Relevance 0.11
This observed temporal association of the progression of P. yoelii 17XL infection with the increasing production of RANTES and its receptors suggests that the two events might be linked.
Positive_regulation (increasing) of Gene_expression (production) of RANTES associated with infection
4) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.98 Pain Relevance 0.10
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
Positive_regulation (abundant) of Gene_expression (expressed) of CCL5 associated with chemokine and chlamydia infection
5) Confidence 0.47 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.61 Pain Relevance 0.16
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of RANTES in brains associated with chemokine
6) Confidence 0.43 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.55 Pain Relevance 0.41
Plasma samples from infected mice at each time point as well as uninfected controls were assayed for RANTES protein expression.
Positive_regulation (assayed) of Gene_expression (expression) of RANTES in Plasma
7) Confidence 0.43 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.48 Pain Relevance 0.03
Briefly, rabbits were immunized with murine CCL5 (Pepro-Tech) and the hyper immune CCL5 antisera obtained was yielded titers of ~1:106 such that 10 ?
Positive_regulation (immune) of Gene_expression (antisera) of CCL5
8) Confidence 0.41 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.53 Pain Relevance 0.12
Briefly, rabbits were immunized with murine CCL5 (Pepro-Tech) and the hyper immune CCL5 antisera obtained was yielded titers of ~1:106 such that 10 ?
Positive_regulation (immune) of Gene_expression (antisera) of CCL5
9) Confidence 0.41 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.54 Pain Relevance 0.12
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Ccl5 associated with chemokine
10) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.89 Pain Relevance 0.62
The expression of RANTES probably enhanced the expression of its receptors.
Positive_regulation (enhanced) of Gene_expression (expression) of RANTES
11) Confidence 0.37 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.61 Pain Relevance 0.39
End othelial cells interacting with P. yoelii 17XL-parasitized erythrocytes have been shown to be induced to produce and present specific chemokines, such as RANTES, which can lure CCR1, CCR3 and CCR5 expressing cells into the brain [36].
Positive_regulation (induced) of Gene_expression (produce) of RANTES in brain associated with chemokine
12) Confidence 0.37 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.39 Pain Relevance 0.15
Although various strains and protocols were used, overall anti-RANTES (CCL5) had no effect in these models, anti-MIP-1?
Positive_regulation (overall) of Gene_expression (overall) of CCL5 associated with sprains and strains
13) Confidence 0.37 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.28 Pain Relevance 0.30
It is likely that the P. yoelii 17XL-induced RANTES production observed in the current study would attract and activate leukocytes towards inflammatory sites to mediate localized hyper-inflammatory responses that could exacerbate the disease pathology in the cerebellum.
Positive_regulation (-) of Gene_expression (production) of RANTES in cerebellum associated with inflammatory response, inflammation and disease
14) Confidence 0.35 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.81 Pain Relevance 0.35
It is likely that the P. yoelii 17XL-induced RANTES production observed in the current study would attract and activate leukocytes towards inflammatory sites to mediate localized hyper-inflammatory responses that could exacerbate the disease pathology in the cerebellum.
Positive_regulation (induced) of Gene_expression (production) of RANTES in cerebellum associated with inflammatory response, inflammation and disease
15) Confidence 0.35 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.81 Pain Relevance 0.35
CCL5 was confirmed to be elevated 2.6-fold during prostate regrowth (Student's t-test, p?
Positive_regulation (elevated) of Gene_expression (2.6-fold) of CCL5
16) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944821 Disease Relevance 0.08 Pain Relevance 0.13
Although various strains and protocols were used, overall anti-RANTES (CCL5) had no effect in these models, anti-MIP-1?
Positive_regulation (overall) of Gene_expression (overall) of anti-RANTES associated with sprains and strains
17) Confidence 0.32 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.27 Pain Relevance 0.30
We have shown that CCL5 inhibition resulted in lower IFN-?
Positive_regulation (resulted) of Neg (inhibition) Gene_expression (inhibition) of CCL5
18) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.90 Pain Relevance 0.20
The observed increased expression of some genes, including nitric oxide synthase 2A [18-21], CD14 antigen [22], T cell receptor alpha locus [23], small inducible cytokine A5 (RANTES) [24], mucin [25,26], tryptases [27,28], cathepsin C [29], and possibly glutathione peroxidase 3 [30], spleen tyrosine kinase [31], and also cathepsin G [32], a serine protease, matches previously published results and confirms the implication of candidate genes already associated with asthma in previous studies.
Positive_regulation (increased) of Spec (observed) Gene_expression (expression) of cytokine A5 in spleen associated with asthma and cytokine
19) Confidence 0.28 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.87 Pain Relevance 0.18
Levels of lung eotaxin-1 (p < 0.04)(Figure 5C), and RANTES (p < 0.02)(Figure 5D) were increased in Siglec-F deficient compared to WT mice challenged with OVA.


Positive_regulation (increased) of Gene_expression (Levels) of RANTES in lung
20) Confidence 0.24 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.08

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