INT176618

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 36.00
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEY1) protein binding transcription factor activity (HEY1) DNA binding (HEY1)
transcription factor binding (HEY1) cytoplasm (HEY1)
Anatomy Link Frequency
blood 1
nasal 1
HEY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 168 100.00 Very High Very High Very High
rheumatoid arthritis 989 99.84 Very High Very High Very High
imagery 54 99.56 Very High Very High Very High
Inflammation 176 99.52 Very High Very High Very High
cytokine 250 99.28 Very High Very High Very High
Angina 5 93.92 High High
antagonist 39 91.20 High High
Bioavailability 6 90.60 High High
Snapping jaw 7 89.32 High High
Bile 18 88.92 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1344 100.00 Very High Very High Very High
Myocardial Infarction 402 100.00 Very High Very High Very High
Frailty 390 100.00 Very High Very High Very High
Pulmonary Disease 305 100.00 Very High Very High Very High
Heart Failure 248 100.00 Very High Very High Very High
Chronic Renal Failure 227 100.00 Very High Very High Very High
Central Sleep Apnea 160 100.00 Very High Very High Very High
Heart Rate Under Development 101 100.00 Very High Very High Very High
Cirrhosis 99 100.00 Very High Very High Very High
Apnoea 49 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we chose to include a diverse set of qualitative studies encompassing various descriptions and interpretations of the CHF experience.


Gene_expression (experience) of CHF associated with myocardial infarction
1) Confidence 0.59 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 0.26 Pain Relevance 0
Knowledge of CHF and its management
Gene_expression (Knowledge) of CHF associated with myocardial infarction
2) Confidence 0.59 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2851714 Disease Relevance 0.48 Pain Relevance 0
expression in late CHF might even be desirable in order to reestablish a favorable MMP/TIMP balance has not been explored.
Gene_expression (expression) of CHF associated with cv general 4 under development
3) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.94 Pain Relevance 0.16
Key features of the CHF phenotype, including pulmonary edema, negative inotropy, ventricular dilatation and hypertrophy, endothelial dysfunction, reduced myocardial ?
Gene_expression (phenotype) of CHF associated with hypertrophy and cv general 4 under development
4) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.26 Pain Relevance 0.44
We describe the first case of CHF presenting in an healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.


Gene_expression (presenting) of CHF associated with fibrosis, splenomegaly, thrombocytopenia and disease
5) Confidence 0.23 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2861643 Disease Relevance 1.84 Pain Relevance 0.19
5.1 How do self-perceived symptoms, care needs, caregiver burden, preferences with regard to life-sustaining treatments, end-of-life care communication and management of patients with severe to very severe COPD, CHF and CRF change over time according to the patients and their closest relatives?
Gene_expression (change) of CHF associated with chronic renal failure, pulmonary disease and heart failure
6) Confidence 0.23 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.66 Pain Relevance 0
It is therefore reasonable to hypothesize that for the families and loved ones of patients with severe to very severe COPD, CHF or CRF there is also great distress, which may increase while the symptoms and care needs of patients with severe to very severe COPD, CHF or CRF progress over time.
Gene_expression (progress) of CHF associated with chronic renal failure, pulmonary disease and heart failure
7) Confidence 0.23 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.41 Pain Relevance 0
2.1 How are the self-perceived symptoms of patients with severe to very severe COPD, CHF or CRF perceived by their closest relatives?
Gene_expression (severe) of CHF associated with chronic renal failure, pulmonary disease and heart failure
8) Confidence 0.23 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.91 Pain Relevance 0
In patients with overt CHF, levels of inflammatory cytokines (TNF-?
Gene_expression (overt) of CHF associated with inflammation, cv general 4 under development and cytokine
9) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.37 Pain Relevance 0.72
As noted above, the diagnosis of CHF in this study was not based on predefined clinical and/or imaging criteria nor was the etiology of CHF (ischemic versus non-ischemic versus other) determined; nonetheless, this study provides tantalizing circumstantial support for the notion that TNF-?
Spec (determined) Gene_expression (diagnosis) of CHF associated with cv general 4 under development and imagery
10) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.29 Pain Relevance 0.27
At present, however, any link between sleep apnea and CHF risk in RA is speculative.


Gene_expression (risk) of CHF associated with apnoea, cv general 4 under development and rheumatoid arthritis
11) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.99 Pain Relevance 0.56
As noted above, the diagnosis of CHF in this study was not based on predefined clinical and/or imaging criteria nor was the etiology of CHF (ischemic versus non-ischemic versus other) determined; nonetheless, this study provides tantalizing circumstantial support for the notion that TNF-?
Gene_expression (etiology) of CHF associated with cv general 4 under development and imagery
12) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.30 Pain Relevance 0.27
CHF with preserved systolic function
Gene_expression (preserved) of CHF associated with cv general 4 under development
13) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.81 Pain Relevance 0.17
This article will review the determinants of central apnea, the specific features of CHF-related central apnea, and outline a management approach


Determinants of central apnea during NREM sleep

Gene_expression (features) of CHF associated with central sleep apnea
14) Confidence 0.21 Published 2008 Journal Heart Fail Rev Section Abstract Doc Link PMC2698052 Disease Relevance 0.63 Pain Relevance 0
The exuberance regarding nasal CPAP therapy in patients with central apnea and CHF did not withstand the rigors of controlled clinical trials.
Gene_expression (therapy) of CHF in nasal associated with central sleep apnea
15) Confidence 0.21 Published 2008 Journal Heart Fail Rev Section Body Doc Link PMC2698052 Disease Relevance 0.91 Pain Relevance 0
The case that we describe is the first reported case of CHF with splenomegaly and thrombocytopenia as the only presenting signs.
Gene_expression (reported) of CHF associated with fibrosis, splenomegaly and thrombocytopenia
16) Confidence 0.20 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2861643 Disease Relevance 1.53 Pain Relevance 0.40
We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.



Gene_expression (presenting) of CHF associated with fibrosis, splenomegaly, thrombocytopenia and disease
17) Confidence 0.18 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2861643 Disease Relevance 1.30 Pain Relevance 0.21
None of these patients was eligible due either to a high LVEF or not having a CHF diagnosis.


Gene_expression (diagnosis) of CHF associated with myocardial infarction
18) Confidence 0.10 Published 2004 Journal BMC Med Res Methodol Section Body Doc Link PMC404462 Disease Relevance 0.10 Pain Relevance 0
Compared to healthy controls who possessed a normal left ventricular remodelling index (LVRI), CHF patients had a significantly reduced LVRI.
Gene_expression (reduced) of CHF associated with heart rate under development
19) Confidence 0.10 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.81 Pain Relevance 0
2.2 Whether and to what extent do self-perceived symptoms and care needs of patients with severe to very severe COPD, CHF or CRF affect caregiver burden?
Gene_expression (severe) of CHF associated with chronic renal failure, pulmonary disease and heart failure
20) Confidence 0.10 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.95 Pain Relevance 0

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