INT176621

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Context Info
Confidence 0.00
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) signal transducer activity (PTGER2) cytoplasm (PTGS2)
Anatomy Link Frequency
osteoblasts 2
PTGS2 (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
Inflammation 4 92.60 High High
metalloproteinase 11 57.92 Quite High
cytokine 4 51.48 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 92.96 High High
Hypercalcemia 7 21.28 Low Low
Anaerobic Bacterial Infections 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Hemorrhage 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some authors have shown that NO can induce and regulate the synthesis of cyclooxygenase 2 (cox-2), the enzyme responsible for production of PGE2 in osteoblasts [42].
cyclooxygenase 2 Regulation (responsible) of Gene_expression (production) of PGE2 in osteoblasts associated with cox2
1) Confidence 0.00 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0.09 Pain Relevance 0.15

General Comments

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