INT176649

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.41
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 6
lymphocytes 2
dendritic cells 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 99.34 Very High Very High Very High
cytokine 46 99.12 Very High Very High Very High
Nerve growth factor 49 87.84 High High
Inflammatory response 1 63.04 Quite High
Antinociceptive 1 43.72 Quite Low
chemokine 14 33.20 Quite Low
Pain 4 33.08 Quite Low
qutenza 3 27.24 Quite Low
vanilloid receptor subtype 1 1 15.96 Low Low
Neuropeptide 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 67 99.36 Very High Very High Very High
INFLAMMATION 25 99.34 Very High Very High Very High
Eczema 108 98.52 Very High Very High Very High
Immunization 19 97.76 Very High Very High Very High
Acanthosis 2 92.64 High High
Infection 82 83.76 Quite High
Respiratory Syncytial Virus 94 83.36 Quite High
Granuloma 1 78.32 Quite High
Disease 38 77.96 Quite High
Salivary Gland Disease 37 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon viral challenge of vaccinated mice, effector CD4+ and CD8+ lymphocytes were rapidly recruited to the BAL.
Negative_regulation (recruited) of Localization (lymphocytes) of CD4 in lymphocytes
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.89 Pain Relevance 0.06
Also Sema3A and NRP-1 of its receptors expressed in dendritic cells and T cells53,54 may be relevant to the immunological effect of Sema3A such as suppression of CD4+ T cells infiltration and IL-4 production observed in the AD-like lesions in NC/Nga mice treated with Sema3A, as above-mentioned.
Negative_regulation (suppression) of Localization (infiltration) of CD4 in dendritic cells associated with eczema
2) Confidence 0.27 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.46 Pain Relevance 0.14
On further extrapolation of this study, the chloroform, n-butanol, and water fractions were investigated for flow cytometric studies on Th1 and Th2 cytokines, wherein, only the chloroform fraction (PLC) showed marked immunosuppressive and anti-inflammatory activity, as evidenced from the downregulation of T-cell surface markers (CD8+/CD4+) and intracellular Th1 (IL-2 and IFN-?)
Negative_regulation (downregulation) of Localization (/) of CD4 in T-cell associated with inflammation and cytokine
3) Confidence 0.24 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.22 Pain Relevance 0.15
CCL5 blockade diminished these cellular responses along with C. muridarum-specific CD4+ T cell secretion of IFN-?
Negative_regulation (diminished) of Localization (secretion) of CD4 in T cell
4) Confidence 0.22 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.63 Pain Relevance 0.11
Marked decreases in the proportions of both CD4 and CD8 positive T-cells were observed.
Negative_regulation (decreases) of Localization (proportions) of CD4 in T-cells
5) Confidence 0.04 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.21 Pain Relevance 0.05

General Comments

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