INT17668

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Context Info
Confidence 0.02
First Reported 1991
Last Reported 2006
Negated 0
Speculated 1
Reported most in Title
Documents 5
Total Number 6
Disease Relevance 1.56
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal horn 4
first segment 1
inferior 1
MCKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 29 100.00 Very High Very High Very High
Morphine 8 99.82 Very High Very High Very High
nociceptor 6 99.76 Very High Very High Very High
tricyclic antidepressant 4 99.10 Very High Very High Very High
Spinal cord 12 98.96 Very High Very High Very High
narcan 2 97.78 Very High Very High Very High
inferior alveolar nerve 2 97.52 Very High Very High Very High
unmyelinated 2 97.28 Very High Very High Very High
glial activation 8 96.64 Very High Very High Very High
Stimulus evoked pain 6 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 14 99.04 Very High Very High Very High
Nervous System Injury 4 97.44 Very High Very High Very High
Pain 6 95.24 Very High Very High Very High
Nociception 4 92.88 High High
Ganglion Cysts 2 53.64 Quite High
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo electrochemical evidence that the tricyclic antidepressant femoxetine potentiates the morphine-induced increase in 5-HT metabolism in the medullary dorsal horn of freely moving rats.
Positive_regulation (increase) of medullary dorsal horn in dorsal horn associated with narcan, dorsal horn, tricyclic antidepressant and morphine
1) Confidence 0.02 Published 1991 Journal Brain Res. Section Title Doc Link 1933281 Disease Relevance 0 Pain Relevance 1.39
The noxious stimulus-dependent induction of c-Fos-like immunoreactivity (Fos-LI) in neurons in the subnucleus oralis and the medullary dorsal horn (MDH) was significantly suppressed by the selective destruction of unmyelinated primary neurons.
Positive_regulation (induction) of medullary dorsal horn in dorsal horn associated with dorsal horn and unmyelinated
2) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10727645 Disease Relevance 0 Pain Relevance 0.51
Fos protein induction in the medullary dorsal horn and first segment of the spinal cord by tooth-pulp stimulation in cats.
Positive_regulation (induction) of medullary dorsal horn in dorsal horn associated with nociceptor, dorsal horn and spinal cord
3) Confidence 0.00 Published 1998 Journal Pain Section Title Doc Link 9539671 Disease Relevance 0.09 Pain Relevance 0.62
In this study, we investigated mechanisms by which glial cell activation in medullary dorsal horn (MDH) would contribute to tactile hypersensitivity following inferior alveolar nerve and mental nerve transection (IAMNT).
Spec (investigated) Positive_regulation (activation) of medullary dorsal horn in inferior associated with inferior alveolar nerve, hypersensitivity and dorsal horn
4) Confidence 0.00 Published 2006 Journal Pain Section Abstract Doc Link 16495005 Disease Relevance 0.61 Pain Relevance 0.36
Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury.
Positive_regulation (Activation) of medullary dorsal horn in dorsal horn associated with nervous system injury, hypersensitivity and dorsal horn
5) Confidence 0.00 Published 2006 Journal Pain Section Title Doc Link 16495005 Disease Relevance 0.76 Pain Relevance 0.42
Fos protein induction in the medullary dorsal horn and first segment of the spinal cord by tooth-pulp stimulation in cats.
Positive_regulation (induction) of medullary dorsal horn in first segment associated with nociceptor, dorsal horn and spinal cord
6) Confidence 0.00 Published 1998 Journal Pain Section Title Doc Link 9539671 Disease Relevance 0.09 Pain Relevance 0.62

General Comments

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