INT1767
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In sepsis, both the coagulation and the fibrinolytic system may be affected, as indicated by decreased activation of thrombomodulin and protein C as well as reduction of anti-fibrinolysis and enhancement of plasminogen activator inhibitor (PAI)-1 expression [2]. | |||||||||||||||
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The maximum enhancement of Pc is attained at a conditioning pressure of 80 ATA. | |||||||||||||||
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In humans, the functional role in vivo was tested in venous thrombosis, where elevated levels of PCI constituted a mild risk factor for thrombosis (Meijers et al. 2002) indicating that of the possible actions of PCI: anticoagulant by inhibition of coagulation enzymes, anti-antifibrinolytic by inhibition of the thrombin activatable fibrinolysis inhibitor (TAFI) activation by thrombin-thrombomodulin, anti-anticoagulant by inhibition of activated protein C and protein C activation by thrombomodulin, and antifibrinolytic by the inhibition of urokinase, the last two options predominate in vivo. | |||||||||||||||
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Activation of platelets and blood coagulation factors may play a major role in triggering the syndrome. | |||||||||||||||
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Australian researchers were perceived to have a competitive advantage in database development and developing research networks that could advance PC research (see TableĀ 1).
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Human factors were also claimed as contributing factors. | |||||||||||||||
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Furthermore, reserpine blocks the increase in Pc during prolonged pressure exposure. | |||||||||||||||
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Different pathophysiologic mechanisms have been proposed: changes in epithelial permeability, pelvic floor dysfunction, mastocytosis, activation of c-fibers, and increase of nerve growth factors and bradykinin. | |||||||||||||||
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Although earlier studies have demonstrated postprandial activation of coagulation factors VII and XII, platelets and monocytes, conclusive evidence for intravascular fibrin formation after a fat-rich meal has not been reported yet. | |||||||||||||||
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Specific research recommendations included the following: researching better modalities to deliver chemotherapy, reducing the deleterious effects of pancreatectomy on nutrition, finding simpler and faster screening tests, developing targeted screening for people at increased risk of PC, and exploring the role of genetic testing in disease prevention.
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Therefore, in good accordance with the study by Liaw and colleagues in adult septic patients [28], we assume that the lack of elevated free APC levels in the presence of activated coagulation in patients with AP in most cases reflected dysfunctional PC activation on the endothelium, or possibly enhanced inhibition of APC by plasma protease inhibitors. | |||||||||||||||
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Due to their location internal iliac artery (IIA) aneurysms are not directly accessible for stent-graft placement. | |||||||||||||||
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The intrapatient variation in PC levels from day to day was large. | |||||||||||||||
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The total PC was measured by activating the bound PC in the wells by Protac (American Diagnostica, Greenwich, CT, USA) and then measuring the amidolytic activity with the chromogenic substrate S-2366 (Chromogenix AB). | |||||||||||||||
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It thus seems that, in patients developing MOF, the PC activation system reached its limits prior to the diagnosis of MOF, resulting in secondary deficiency of PC concomitantly with a failure to maintain steady APC levels similar to those observed in AP patients without MOF. | |||||||||||||||
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In rabbits, both the stimulation of alpha1-adrenoceptors and ischemic preconditioning (PC) reduce infarct size. | |||||||||||||||
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The consequence is an increased flow velocity and therefore increased shear stress in the collateral arteries, which leads to a marked activation of the endothelium with the subsequent morphological changes, vascular remodeling and activation of growth factors involved in angiogenesis and arteriogenesis. | |||||||||||||||
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Since LDL has a high affinity for heparin and heparin for growth factors, LDL accumulation may be a mechanism for the concentration of such materials in the intima. | |||||||||||||||
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These results seem to exclude the possibility of enhanced PC breakdown and further suggest that the main inhibitory effect is on the CDP-choline pathway for PC biosynthesis. | |||||||||||||||
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Activation of platelets and blood coagulation factors may play a major role in triggering the syndrome. | |||||||||||||||
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General Comments
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