INT17674

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 1.73
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
SCN 8
neurons 4
brain 3
optic chiasm 2
MT2 1
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 314 100.00 Very High Very High Very High
gABA 300 100.00 Very High Very High Very High
Somatostatin 153 100.00 Very High Very High Very High
Raphe 133 100.00 Very High Very High Very High
Glutamate receptor 49 99.58 Very High Very High Very High
Neuropeptide 212 99.12 Very High Very High Very High
tetrodotoxin 22 98.20 Very High Very High Very High
Neurotransmitter 867 97.76 Very High Very High Very High
agonist 127 95.68 Very High Very High Very High
nMDA receptor antagonist 1 92.80 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 56 98.28 Very High Very High Very High
Sleep Disorders 147 96.88 Very High Very High Very High
Aging 48 87.24 High High
Generalized Anxiety Disorder 18 86.60 High High
Anxiety 4 86.36 High High
Sleep Initiation And Maintenance Disorders 12 86.00 High High
Substance Withdrawal Syndrome 2 85.12 High High
Cognitive Disorder 16 82.36 Quite High
Drug Dependence 4 77.56 Quite High
Pain 1 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the optic nerve released 3H-Glu, 3H-Asp but not 3H-GABA, while stimulation of the SCN released all three.
Localization (released) of SCN in SCN associated with gaba
1) Confidence 0.61 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 2872946 Disease Relevance 0 Pain Relevance 0.34
In the present study, we showed that application of NMDA at circadian time (CT) 12-15 induced significant glutamate release from the SCN region in vitro.
Localization (release) of SCN in SCN associated with glutamate
2) Confidence 0.54 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9853711 Disease Relevance 0 Pain Relevance 0.48
SS producing neurons of the SCN are located in both the core and shell portions [237] and form a distinct peptidergic neuronal group.
Localization (located) of SCN in neurons associated with somatostatin
3) Confidence 0.53 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.46
Synapse of SS fibres on VIP and AVP neurons and presence of SS receptors in the SCN is suggestive of a regulatory role for SS on other peptidergic neurons.
Localization (presence) of SCN in peptidergic neurons associated with somatostatin
4) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.17 Pain Relevance 0.71
The location of the SCN, in the anterior hypothalamus, bilaterally next to third ventricle and above the optic chiasm, and the afferent and efferent projections of the SCN are similar in humans and other mammals.
Localization (location) of SCN in optic chiasm
5) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.09
These SCN neurons are retinorecipient and are found in the core of the SCN.
Localization (retinorecipient) of SCN in neurons
6) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.17
Calretinin (CALR) is another variety of neurons found in the SCN (in the core ventral part) that appears to be co-localized with VIP neurons.
Localization (localized) of SCN in ventral
7) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.03
Different types of glutamate receptors were identified and localized in the SCN using in situ hybridization and immunocytochemistry [51].
Localization (localized) of SCN associated with glutamate receptor
8) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.09 Pain Relevance 0.83
While considering the action of GABA in the SCN, whether inhibitory or excitatory, extrinsic GABA sources such as from IGL [116] and release of GABA from SCN terminals implicated in transmission of light information should also be looked into to visualize a clearer picture.
Localization (release) of SCN associated with gaba
9) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.09 Pain Relevance 0.55
The location of the SCN, in the anterior hypothalamus, bilaterally next to third ventricle and above the optic chiasm, and the afferent and efferent projections of the SCN are similar in humans and other mammals.
Localization (location) of SCN in optic chiasm
10) Confidence 0.46 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.08
This, together with an increase in frequency of spontaneous and miniature IPSCs, implies the presence of presynaptic receptors that facilitate GABA release from SCN and possibly other synaptic terminals.
Localization (release) of SCN in SCN associated with gaba
11) Confidence 0.46 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19571188 Disease Relevance 0 Pain Relevance 0.36
The type of Ca2+ buffering proteins and their localization within the SCN may differ depending on the particular animal species [34], [35], the developmental stages [36], and the circadian timings [37].
Localization (localization) of SCN in developmental stages
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0
AVP is synthesized and secreted by the SCN in a circadian pattern.
Localization (secreted) of SCN
13) Confidence 0.44 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.07 Pain Relevance 0.05
Taken all together, we could conclude that the observed spontaneous SCN Ca2+ spikes were not intrinsic to SCN but induced by fluo-4 dye loading.
Neg (not) Localization (intrinsic) of SCN in spikes
14) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.15
VP release from SCN explants was consistently attenuated during TTX treatment, with the amplitude of this effect depending on the time of administration.
Localization (release) of SCN in SCN associated with tetrodotoxin
15) Confidence 0.42 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1933388 Disease Relevance 0 Pain Relevance 0.51
The discrete localization of little SAAS within the central SCN predicts a role in processing afferent signals.
Localization (localization) of SCN
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.04
Little SAAS release from the SCN slice is low during subjective nighttime [7], coinciding with high SCN sensitivity to little SAAS.
Localization (release) of SCN
17) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.16
Experiments utilized 500-µm coronal brain slices containing the mid-SCN, prepared during daytime ?
Localization (utilized) of SCN in brain
18) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.06 Pain Relevance 0
Experiments utilized 500-µm coronal brain slices containing the mid-SCN, prepared during daytime ?
Localization (prepared) of SCN in brain
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.06 Pain Relevance 0
Why does the SCN express and release such an abundance of neuropeptides?
Localization (release) of SCN associated with neuropeptide
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.05 Pain Relevance 0.19

General Comments

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