INT1768

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Context Info
Confidence 0.41
First Reported 1979
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.80
Pain Relevance 1.51

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peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
PC-3 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 2 99.76 Very High Very High Very High
Morphine 10 98.20 Very High Very High Very High
monoamine 1 91.84 High High
anesthesia 10 91.44 High High
tolerance 1 84.32 Quite High
cytokine 6 80.96 Quite High
Inflammation 6 69.96 Quite High
addiction 3 69.04 Quite High
agonist 15 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 38 100.00 Very High Very High Very High
Sepsis 32 98.32 Very High Very High Very High
Thrombosis 68 89.40 High High
Convulsion 2 88.92 High High
Syndrome 1 88.56 High High
Necrosis 4 82.48 Quite High
Cancer 12 82.12 Quite High
Fever 4 76.84 Quite High
Hypothermia 92 76.16 Quite High
Body Weight 5 71.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sepsis, both the coagulation and the fibrinolytic system may be affected, as indicated by decreased activation of thrombomodulin and protein C as well as reduction of anti-fibrinolysis and enhancement of plasminogen activator inhibitor (PAI)-1 expression [2].
Negative_regulation (reduction) of Positive_regulation (activation) of protein C as associated with sepsis
1) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.04 Pain Relevance 0.08
In sepsis, both the coagulation and the fibrinolytic system may be affected, as indicated by decreased activation of thrombomodulin and protein C as well as reduction of anti-fibrinolysis and enhancement of plasminogen activator inhibitor (PAI)-1 expression [2].
Negative_regulation (decreased) of Positive_regulation (activation) of protein C as associated with sepsis
2) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.04 Pain Relevance 0.08
Furthermore, reserpine blocks the increase in Pc during prolonged pressure exposure.
Negative_regulation (blocks) of Positive_regulation (increase) of Pc
3) Confidence 0.36 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 3804908 Disease Relevance 0.25 Pain Relevance 0.33
The PC increase following formalin administration to morphine dependent rats was higher than in naive rats. 0.1 mg/kg s.c. of dexamethasone completely inhibited PC increase after formalin in naive rats, but the dexamethasone inhibition in morphine dependent rats was not complete even with a larger dose, i.e. 10 mg/kg s.c.
Negative_regulation (inhibited) of Positive_regulation (increase) of PC associated with dexamethasone and morphine
4) Confidence 0.04 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 231553 Disease Relevance 0.13 Pain Relevance 1.03
In contrast, in PC-3 the expression of c-fos was not increased by goserelin incubation and seemed to be slightly reduced by irradiation (when compared to control).
Negative_regulation (reduced) of Neg (not) Positive_regulation (increased) of PC in PC-3 associated with reprotox - general 1
5) Confidence 0.02 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC2034383 Disease Relevance 0.34 Pain Relevance 0

General Comments

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