INT17686

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Context Info
Confidence 0.36
First Reported 1983
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 72
Total Number 75
Disease Relevance 81.85
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 11
arm 4
blood 3
liver 2
endothelial cell 2
Hdl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 45 100.00 Very High Very High Very High
Angina 70 99.96 Very High Very High Very High
psoriasis 315 99.92 Very High Very High Very High
rheumatoid arthritis 43 99.58 Very High Very High Very High
beta blocker 11 99.30 Very High Very High Very High
Restless leg syndrome 6 98.84 Very High Very High Very High
Inflammation 510 97.26 Very High Very High Very High
alcohol 150 97.20 Very High Very High Very High
Osteoarthritis 122 95.16 Very High Very High Very High
antagonist 30 94.80 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5673 100.00 Very High Very High Very High
Coronary Heart Disease 673 100.00 Very High Very High Very High
Diabetes Mellitus 271 100.00 Very High Very High Very High
Hypertension 152 100.00 Very High Very High Very High
Nicotine Addiction 149 100.00 Very High Very High Very High
Hypertriglyceridemia 42 99.96 Very High Very High Very High
Variant Angina Pectoris 5 99.96 Very High Very High Very High
Psoriasis 530 99.92 Very High Very High Very High
Coronary Artery Disease 231 99.80 Very High Very High Very High
Hypolipidemia 43 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-density lipoprotein cholesterol and HDL/TC were significantly reduced in cigarette smokers, and HDL/TC was significantly reduced in men with myocardial infarction or angina pectoris and (albeit marginally) in diabetes mellitus as well.
Negative_regulation (reduced) of High-density lipoprotein cholesterol associated with angina, nicotine addiction, diabetes mellitus, myocardial infarction and disorder of lipid metabolism
1) Confidence 0.36 Published 1986 Journal Prev Med Section Abstract Doc Link 3797389 Disease Relevance 2.35 Pain Relevance 0.10
BACKGROUND: Elevated triglyceride-rich lipoproteins and reduced high-density lipoproteins (HDL) are associated with the development of intermittent claudication (IC), a life-limiting symptom of peripheral arterial disease.
Negative_regulation (reduced) of HDL associated with restless leg syndrome, peripheral arterial disease and disorder of lipid metabolism
2) Confidence 0.36 Published 2003 Journal Atherosclerosis Section Abstract Doc Link 14644405 Disease Relevance 0.53 Pain Relevance 0.25
Low levels of HDL have been shown to be independent predictors of risk.
Neg (independent) Negative_regulation (predictors) of HDL associated with disorder of lipid metabolism
3) Confidence 0.31 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2988622 Disease Relevance 1.06 Pain Relevance 0.05
The apo A-1 remained strongly inversely associated with CHD events in IDEAL, and HDL particle size and apo B in EPIC-Norfolk at any level of HDL.
Negative_regulation (level) of HDL associated with coronary heart disease and disorder of lipid metabolism
4) Confidence 0.31 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.72 Pain Relevance 0
Recent studies have shown that the inhibitory effect of HDL may be related to the presence of tissue pathway factor inhibitor (TPFI) in this lipoprotein (Lesnik et al 1993).
Negative_regulation (effect) of HDL associated with disorder of lipid metabolism
5) Confidence 0.30 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.19 Pain Relevance 0
Hypertriglyceridemia associated with decreases in high density lipoprotein (HDL) cholesterol has occurred in 25 percent of patients and requires monitoring during treatment.
Negative_regulation (decreases) of high density lipoprotein associated with hyperlipidemia and disorder of lipid metabolism
6) Confidence 0.30 Published 1984 Journal Drug Intell Clin Pharm Section Abstract Doc Link 6232121 Disease Relevance 1.09 Pain Relevance 0.16
In the general population, lower-than-normal HDL-C levels are inversely correlated with CHD; the risk of a coronary event is thought to increase 2% for every 1% decrease in HDL.
Negative_regulation (decrease) of HDL associated with coronary heart disease and disorder of lipid metabolism
7) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.62 Pain Relevance 0
In the latest report, the NCEP ATP-III guidelines clearly indicate that low HDL is a significant and independent risk factor for CHD.6 The relationship is inversely proportional, such that 1 mg/dL rise in HDL imparts 2% to 3% reduction in CHD risk.7 Low HDL is frequently associated with high triglycerides and remnant lipoprotein levels.
Negative_regulation (reduction) of HDL associated with coronary heart disease and disorder of lipid metabolism
8) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 2.19 Pain Relevance 0
Therefore, inhibition of CETP activity can potentially provide a therapeutic benefit for patients with CHD by allowing HDL particles to accumulate and be more available for augmenting the RCT process that scavenges cholesterol from the tissues.
Negative_regulation (allowing) of HDL associated with coronary heart disease and disorder of lipid metabolism
9) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.96 Pain Relevance 0
Because the inhibitory effect of HDL is observed even after removal of these lipoproteins from the endothelial cell culture, it seems not to be related to the scavenging of free radicals by antioxidants contained in HDL.
Negative_regulation (effect) of HDL in endothelial cell associated with disorder of lipid metabolism
10) Confidence 0.22 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0.22
The antiapoptotic effect of HDL was abolished by protein synthesis inhibitors.
Negative_regulation (effect) of HDL associated with disorder of lipid metabolism
11) Confidence 0.22 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.86 Pain Relevance 0.03
This correlation may reflect the in vitro inhibitory effect of HDL on tPA and PAI secretion by the endothelium (Ren and Shen 2000).
Negative_regulation (effect) of HDL in endothelium associated with disorder of lipid metabolism
12) Confidence 0.22 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.22 Pain Relevance 0.03
In contrast, ranitidine has no effect, or may even decrease HDL levels.
Spec (may) Negative_regulation (decrease) of HDL associated with disorder of lipid metabolism
13) Confidence 0.21 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 1.12 Pain Relevance 0.18
Also, there were six boys having bottom decile levels of high-density lipoprotein cholesterol (HDL-C); all six came from kindreds with at least one first degree relative also having bottom decile HDL-C.
Negative_regulation (decile) of high-density lipoprotein cholesterol associated with disorder of lipid metabolism
14) Confidence 0.21 Published 1986 Journal Pediatrics Section Abstract Doc Link 3951912 Disease Relevance 1.01 Pain Relevance 0.60
Patients in the low-dose group receiving combination treatment achieved 14% (1000 mg/20 mg) and 23% (2000 mg/20 mg) reductions in non-HDL compared with a 7% reduction with 20 mg simvastatin therapy alone.
Negative_regulation (reductions) of HDL associated with disorder of lipid metabolism
15) Confidence 0.17 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.45 Pain Relevance 0
We sought to determine the association between a low level of high-density lipoprotein cholesterol (HDL-C) and VAP.
Negative_regulation (level) of high-density lipoprotein cholesterol associated with angina and disorder of lipid metabolism
16) Confidence 0.12 Published 2010 Journal Int. J. Cardiol. Section Abstract Doc Link 19108908 Disease Relevance 0.82 Pain Relevance 0.44
Retinoids have the most potent activity on increasing the levels of triglycerides, total cholesterol, LDL cholesterol, and VLDL cholesterol and simultaneously decreasing the HDL fraction [137–140].
Negative_regulation (decreasing) of HDL associated with disorder of lipid metabolism
17) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.14 Pain Relevance 0.11
It was also reported that apoA1 sequestration in the inflamed tissues might lead to reduced HDL-C serum levels and thus increase the risk of cardiovascular disease in psoriatic patients [81].
Negative_regulation (reduced) of HDL associated with psoriasis, cardiovascular disease and disorder of lipid metabolism
18) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.16 Pain Relevance 0.03
In addition, reduced dietary fat has been shown to significantly decrease HDL-C2 fractions, which has been linked to antiatherogenic effects of HDL-C (Berglund et al 1999).
Negative_regulation (decrease) of HDL in fat associated with disorder of lipid metabolism
19) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.97 Pain Relevance 0.04
However, a simultaneous decrease in LDL-C with low fat diets appears to be more clinically important than the reduction in HDL-C levels.
Negative_regulation (reduction) of HDL in fat associated with disorder of lipid metabolism
20) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.00 Pain Relevance 0.03

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