INT17688

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.48
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IKZF1) intracellular (IKZF1) cell cycle (IKZF1)
DNA binding (IKZF1) cytoplasm (IKZF1)
Anatomy Link Frequency
immune cells 1
neurons 1
IKZF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 99.98 Very High Very High Very High
Action potential 44 99.46 Very High Very High Very High
potassium channel 4 99.44 Very High Very High Very High
addiction 4 96.40 Very High Very High Very High
Kappa opioid receptor 2 95.60 Very High Very High Very High
qutenza 5 94.60 High High
action potential duration 20 92.96 High High
opioid receptor 1 88.60 High High
MU agonist 1 87.80 High High
Enkephalin 1 77.48 Quite High
Disease Link Frequency Relevance Heat
Disease 20 82.68 Quite High
Andersen Syndrome 6 81.72 Quite High
Arrhythmia Under Development 12 76.12 Quite High
Syndrome 45 71.72 Quite High
Adhesions 2 65.08 Quite High
Arrhythmias 2 Under Development 8 50.20 Quite High
Cardiovascular Disorder Under Development 4 50.00 Quite Low
Heart Rate Under Development 11 48.92 Quite Low
Malignant Neoplastic Disease 3 38.36 Quite Low
Hypertrophic Cardiomyopathy 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the observed changes are mediated by an increase in intracellular calcium, which leads to an increase in rectification of IK1, as well as to activation of another membrane-conductance system, perhaps the Na-Ca exchange or the Ca(2+)-activated, nonselective current.
Positive_regulation (increase) of IK1
1) Confidence 0.50 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1934360 Disease Relevance 0 Pain Relevance 0.15
Delta-opioids activated AP-1, c-fos, activating transcription factor 2, Ikaros-1 and Ikaros-2 transcription factors in immune cells.
Positive_regulation (activated) of Ikaros in immune cells associated with opioid
2) Confidence 0.49 Published 2006 Journal Neuroimmunomodulation Section Abstract Doc Link 16612131 Disease Relevance 0 Pain Relevance 1.08
Short duration (1h) exposure of dissociated sensory neurons to NTFs increased numbers of TRPV1-positive neurons, but not of TRPV3, Nav 1.8 and IK1 and the morphological size-distribution remained similar to intact post-mortem DRG neurons.
Positive_regulation (increased) of IK1 in neurons
3) Confidence 0.39 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16481104 Disease Relevance 0 Pain Relevance 0.44
AP triangulation is strongly dependent on IK1 and IKr, as in humans.
Positive_regulation (dependent) of IK1 associated with action potential
4) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.34
KCNJ2 encodes an inwardly rectifier potassium channel, Kir2.1, the ionic channel conducting the IK1 current.
Positive_regulation (conducting) of IK1 associated with potassium channel
5) Confidence 0.04 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 0.48 Pain Relevance 0.11

General Comments

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