INT176888

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 11.68
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)
Anatomy Link Frequency
bone marrow 3
fat 2
liver 1
monocytes 1
spine 1
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 757 99.96 Very High Very High Very High
Inflammation 23 95.88 Very High Very High Very High
fibrosis 38 91.84 High High
Inflammatory response 4 85.68 High High
cytokine 81 81.60 Quite High
Demyelination 1 79.28 Quite High
Multiple sclerosis 10 74.80 Quite High
Spinal cord 16 73.52 Quite High
Dismenorea 12 71.24 Quite High
alcohol 4 69.72 Quite High
Disease Link Frequency Relevance Heat
Mitral Valve Insufficiency 66 100.00 Very High Very High Very High
Cancer 373 99.04 Very High Very High Very High
Infection 361 98.76 Very High Very High Very High
Primitive Neuroectodermal Tumors 8 98.28 Very High Very High Very High
Brain Hemorrhage 4 97.24 Very High Very High Very High
Injury 27 96.92 Very High Very High Very High
INFLAMMATION 26 95.88 Very High Very High Very High
Syndrome 28 95.40 Very High Very High Very High
Malignant Neoplastic Disease 56 94.68 High High
Hypoxia 32 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second would be a careful review of the whole spine contrast enhanced MRI and if needed, a repeat MRI.
Positive_regulation (enhanced) of MRI in spine
1) Confidence 0.67 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995611 Disease Relevance 1.33 Pain Relevance 0.21
As availability of MR increases, so the education of anaesthetists, who are occasionally required to provide a service, must be considered.
Positive_regulation (increases) of MR
2) Confidence 0.53 Published 2010 Journal Anaesthesia Section Abstract Doc Link PMC2904502 Disease Relevance 0.09 Pain Relevance 0.05
Interventional procedures and intra-operative MR
Positive_regulation (operative) of MR
3) Confidence 0.38 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.09 Pain Relevance 0.04
Increased requirements for MR imaging in intensive care and postoperative patients have increased the need for repeated training.
Positive_regulation (requirements) of MR associated with imagery
4) Confidence 0.38 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.16 Pain Relevance 0.05
It is recommended that patients implanted with neurostimulators should not undergo MR.
Neg (not) Positive_regulation (undergo) of MR
5) Confidence 0.35 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.17 Pain Relevance 0.12
Editorials in the American and European literature concluded that the risk:benefit ratio for patients with pacemakers undergoing MR has shifted towards safety, if guidelines are followed [16, 17].
Positive_regulation (undergoing) of MR
6) Confidence 0.35 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0 Pain Relevance 0.04
Significant exercise-induced increases in MR (increase in ERO ?
Positive_regulation (increase) of MR associated with mitral valve insufficiency
7) Confidence 0.13 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 1.19 Pain Relevance 0
Significant exercise-induced increases in MR (increase in ERO ?
Positive_regulation (increases) of MR associated with mitral valve insufficiency
8) Confidence 0.13 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC514499 Disease Relevance 1.20 Pain Relevance 0
Functional ligand binding and transcriptional profiling studies [19,31] reveal that the MR is markedly upregulated on alternatively activated MØ.
Positive_regulation (upregulated) of MR
9) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.70 Pain Relevance 0.07
Protein expression studies and transcriptional profiling have shown that IL-4 induces upregulation of several receptors, including the mannose receptor (MR) on monocytes and MØ [18,19].
Positive_regulation (upregulation) of MR in monocytes
10) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.45 Pain Relevance 0.12
Note the fatty conversion of the bone marrow in the irradiation field, L1 to L3, is only apparent on the non-fat saturated non-enhanced MR image.
Positive_regulation (enhanced) of MR in fat
11) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.35 Pain Relevance 0.03
Although investigated since 1993 [23], dynamic Gd-DTPA-enhanced MR studies have not shown clinical significance so far.
Positive_regulation (enhanced) of MR
12) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0 Pain Relevance 0
This possible synergy between these anti-angiogenesis drugs and cytotoxic drugs or irradiation, as a function of apparent tumor microvascular hyperpermeability, can also be interrogated with MMCM-enhanced MR imaging.


Positive_regulation (enhanced) of MR associated with cancer and imagery
13) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.62 Pain Relevance 0.08
The signal intensity of the post-transplant bone marrow on T1-weighted MR images is usually increased compared to age-matched controls [84].
Positive_regulation (increased) of MR in bone marrow
14) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.27 Pain Relevance 0
Fig. 1T1-weighted non-enhanced (a) and fat saturated contrast enhanced (b) MR images after radiation therapy of a focal PNET tumor infiltration in L 2.
Positive_regulation (enhanced) of MR in fat associated with cancer and primitive neuroectodermal tumors
15) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.41 Pain Relevance 0.06
Dynamic Gd-DTPA-enhanced MR scans documented repetitively an increased blood volume (i.e., increased enhancement) of neoplastic infiltrations compared to the normal bone marrow [22, 23, 41].
Positive_regulation (enhanced) of MR in bone marrow
16) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.27 Pain Relevance 0.03
A conversion of a diffuse to a focal MR imaging pattern of marrow involvement, reduction, but not disappearance in lesion size and number, and persistant peripheral lesion enhancement on contrast-enhanced MR images (Fig. 6) have been described in association with a response to standard chemotherapy [58, 60].
Positive_regulation (enhanced) of MR associated with imagery
17) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.68 Pain Relevance 0.08
With increasing age, a conversion from this highly cellular marrow in children to fatty marrow in adults occurs with a gradual increase of the bone marrow signal on T1-weighted MR images and a gradual decline of the bone marrow signal on STIR- or fat saturated T2-weighted MR images over time.
Positive_regulation (increase) of MR in bone marrow
18) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0 Pain Relevance 0.06
This, combined with the observation that MDDC express both DC-SIGN and MR [22], and our demonstration that the presence of MR alone is sufficient to confer DV binding to transfected cells, suggest that glycosylation at Asn-67 may be relevant for mediating MR binding, in addition to that of DC-SIGN.
Positive_regulation (mediating) of MR
19) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0 Pain Relevance 0
The observation that antibodies to either MR or DC-SIGN can inhibit infection to such an extensive degree suggests that DV is likely to be using both MR and DC-SIGN for entry on cells that express both.
Positive_regulation (using) of MR associated with infection
20) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.66 Pain Relevance 0

General Comments

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