INT17692

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.99
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C5AR1) plasma membrane (C5AR1) signal transducer activity (C5AR1)
Anatomy Link Frequency
peritoneal fluid 1
plasma 1
C5AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 3 99.94 Very High Very High Very High
cINOD 8 99.84 Very High Very High Very High
Analgesic 1 99.54 Very High Very High Very High
Inflammatory response 1 96.80 Very High Very High Very High
neuralgia 1 95.76 Very High Very High Very High
Inflammation 19 92.56 High High
Pain 1 64.28 Quite High
ischemia 2 50.00 Quite Low
Angina 1 50.00 Quite Low
Arthritis 1 26.40 Quite Low
Disease Link Frequency Relevance Heat
Familial Mediterranean Fever 15 99.04 Very High Very High Very High
INFLAMMATION 24 96.80 Very High Very High Very High
Herpes Zoster 2 96.40 Very High Very High Very High
Neuralgia 1 95.76 Very High Very High Very High
Targeted Disruption 4 95.64 Very High Very High Very High
Herpes Simplex Virus Infection 2 95.36 Very High Very High Very High
Pneumonia 2 93.92 High High
Infection 16 92.84 High High
Disease 9 85.76 High High
Herpes Simplex Virus 1 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action seems to be associated with the inhibition of local anaphylatoxin release (C3a and C5a) which are responsible for the acute evolution of the lesions produced by viruses of the Zoster-Varicella group and with a quick lethal effect on the parasitized cells which are selectively eliminated without affecting the adjoining normal cells of the host.
Negative_regulation (inhibition) of C5a associated with herpes zoster
1) Confidence 0.57 Published 1993 Journal Roum Arch Microbiol Immunol Section Abstract Doc Link 7827366 Disease Relevance 0.61 Pain Relevance 0.13
Moreover, the peritoneal fluid of FMF patients contains abnormally low levels of the inhibitor of complement fragment C5a and interleukin 8.
Negative_regulation (inhibitor) of C5a in peritoneal fluid associated with familial mediterranean fever
2) Confidence 0.42 Published 2004 Journal Sante Section Abstract Doc Link 15745878 Disease Relevance 1.50 Pain Relevance 0.19
Coronary sinus plasma levels of the anaphylatoxin C5a always remained below 4 ng/ml in patients undergoing pacing.
Negative_regulation (remained) of C5a in plasma
3) Confidence 0.41 Published 1991 Journal Circulation Section Body Doc Link 1934381 Disease Relevance 0 Pain Relevance 0
We have studied discrete events in the process of signal transduction: NSAIDs but not a related analgesic drug (acetaminophen), inhibited aggregation in response to the chemoattractants f-Met-Leu-Phe (FMLP), leukotriene B4, and C5a.
Negative_regulation (inhibited) of C5a associated with paracetamol, analgesic and cinod
4) Confidence 0.41 Published 1990 Journal Inflammation Section Abstract Doc Link 2138998 Disease Relevance 0.16 Pain Relevance 0.72
Modulation of C5a responses by S. aureus proceeds through inhibition of the C5a receptor (C5aR).
Negative_regulation (inhibition) of C5a
5) Confidence 0.09 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.35 Pain Relevance 0
Efb and Ecb are very potent inhibitors of C5a responses in vitro and in vivo [22].
Negative_regulation (inhibitors) of C5a
6) Confidence 0.08 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.38 Pain Relevance 0

General Comments

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