INT17694

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Context Info
Confidence 0.44
First Reported 1991
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PF4) extracellular region (PF4)
Anatomy Link Frequency
plasma 1
platelet 1
PF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 83.76 Quite High
cva 24 63.00 Quite High
ischemia 2 50.00 Quite Low
Angina 1 50.00 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 6 97.88 Very High Very High Very High
Pain 6 83.76 Quite High
Hemorrhage 13 82.72 Quite High
Peripheral Arterial Disease 12 80.96 Quite High
Hematoma 1 77.76 Quite High
Cv General 3 Under Development 11 63.00 Quite High
Disease 6 51.20 Quite High
Coronary Artery Disease 2 50.00 Quite Low
Pressure Volume 2 Under Development 1 40.92 Quite Low
Hepatic Insufficiency 1 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all patients, there was neither platelet sequestration nor platelet alpha-granule release (no changes of beta-thromboglobulin/platelet factor 4 levels) into the coronary sinus plasma.
Neg (no) Regulation (changes) of platelet factor 4 in plasma
1) Confidence 0.44 Published 1991 Journal Circulation Section Body Doc Link 1934381 Disease Relevance 0 Pain Relevance 0
Heparin-induced thrombocytopenia (HIT) is another well known complication of heparin, its incidence being approximately 0.8%, with LMWH, about 3-fold lower than with UFH.67,68 HIT is caused by heparin-dependent antibodies (usually immunoglobulin G) binding a confirmationally modified epitope on platelet factor 4 (PF4), its modified structure being subsequently recognized as a foreign protein by the immunocompetent cells of the patients.
Regulation (epitope) of PF4 in platelet associated with heparin-induced thrombocytopenia
2) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762431 Disease Relevance 1.18 Pain Relevance 0.12

General Comments

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