From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1991
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PF4) extracellular region (PF4)
Anatomy Link Frequency
plasma 1
platelet 1
PF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 83.76 Quite High
cva 24 63.00 Quite High
ischemia 2 50.00 Quite Low
Angina 1 50.00 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 6 97.88 Very High Very High Very High
Pain 6 83.76 Quite High
Hemorrhage 13 82.72 Quite High
Peripheral Arterial Disease 12 80.96 Quite High
Hematoma 1 77.76 Quite High
Cv General 3 Under Development 11 63.00 Quite High
Disease 6 51.20 Quite High
Coronary Artery Disease 2 50.00 Quite Low
Pressure Volume 2 Under Development 1 40.92 Quite Low
Hepatic Insufficiency 1 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all patients, there was neither platelet sequestration nor platelet alpha-granule release (no changes of beta-thromboglobulin/platelet factor 4 levels) into the coronary sinus plasma.
Neg (no) Regulation (changes) of platelet factor 4 in plasma
1) Confidence 0.44 Published 1991 Journal Circulation Section Body Doc Link 1934381 Disease Relevance 0 Pain Relevance 0
Heparin-induced thrombocytopenia (HIT) is another well known complication of heparin, its incidence being approximately 0.8%, with LMWH, about 3-fold lower than with UFH.67,68 HIT is caused by heparin-dependent antibodies (usually immunoglobulin G) binding a confirmationally modified epitope on platelet factor 4 (PF4), its modified structure being subsequently recognized as a foreign protein by the immunocompetent cells of the patients.
Regulation (epitope) of PF4 in platelet associated with heparin-induced thrombocytopenia
2) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762431 Disease Relevance 1.18 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools