INT17701

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 103
Total Number 105
Disease Relevance 64.23
Pain Relevance 8.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
parathyroid 11
chondrocytes 6
MDA-MB-231 5
osteoclasts 4
osteoblasts 2
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 381 100.00 Very High Very High Very High
Pain 110 100.00 Very High Very High Very High
cytokine 99 100.00 Very High Very High Very High
corticosteroid 4 100.00 Very High Very High Very High
Pain threshold 3 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
rheumatoid arthritis 101 99.96 Very High Very High Very High
Clonidine 4 99.78 Very High Very High Very High
Arthritis 52 98.88 Very High Very High Very High
Serotonin 1 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2781 100.00 Very High Very High Very High
Hypercalcemia 457 100.00 Very High Very High Very High
Osteoarthritis 252 100.00 Very High Very High Very High
Pain 107 100.00 Very High Very High Very High
Rheumatoid Arthritis 101 99.96 Very High Very High Very High
Malignant Neoplastic Disease 123 99.84 Very High Very High Very High
Osteolysis 217 99.80 Very High Very High Very High
Lymphatic System Cancer 39 99.68 Very High Very High Very High
Hypertrophy 39 99.68 Very High Very High Very High
Osteoporosis 297 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicated that the hypercalcemia was due to production of PTHrP by the leukemic cells.
Gene_expression (production) of PTHrP associated with hypercalcemia
1) Confidence 0.78 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 11925871 Disease Relevance 0.93 Pain Relevance 0.10
To investigate how PTHrP might be involved in the process of neointimal formation after balloon angioplasty, we examined PTHrP expression in balloon-denuded rat carotid arteries and human coronary arteries that had been retrieved by directional atherectomy.
Spec (examined) Gene_expression (expression) of PTHrP
2) Confidence 0.78 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.22 Pain Relevance 0
In situ hybridization and immunohistochemistry revealed that PTHrP expression in balloon-denuded carotid arteries was mainly localized to the neointima.
Gene_expression (expression) of PTHrP associated with neointima
3) Confidence 0.78 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.36 Pain Relevance 0.12
The number of intimal cells that expressed PTHrP protein was significantly higher in restenotic (407 +/- 53 cells/mm2; range, 143 to 739) than in stable angina (50 +/- 12 cells/mm2; range, 18 to 132; P<.05) or unstable angina (129 +/- 16 cells/mm2; range, 21 to 232; P<.05) specimens.
Gene_expression (expressed) of PTHrP protein associated with angina
4) Confidence 0.78 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.41 Pain Relevance 0.19
These data demonstrate that PTHrP gene expression in VSMCs markedly increases during neointimal formation, supporting the hypothesis that PTHrP may play an important role in vascular stenosis as a regulator of VSMC proliferation.
Gene_expression (expression) of PTHrP associated with pathologic constriction
5) Confidence 0.78 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.44 Pain Relevance 0.19
The detection of the PTHRP in the tumor extract and the positive immunohistochemical staining for this in the tumor cells suggested that the humoral hypercalcemia was definitely caused by its associated tumor production.
Gene_expression (detection) of PTHRP associated with cancer and hypercalcemia
6) Confidence 0.77 Published 1995 Journal Surg. Today Section Abstract Doc Link 8640024 Disease Relevance 1.17 Pain Relevance 0.08
METHODS: Stable breast carcinoma MDA-MB-231 cell lines were constructed that expressed mutant TGFbeta receptors, Smad proteins, or estrogen receptor (ER)-alpha and were used to determine the role of TGFbeta in modulating tumor production of PTHrP.
Gene_expression (production) of PTHrP in MDA-MB-231
7) Confidence 0.75 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.18 Pain Relevance 0
Tumor-produced parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption, is a major mediator of the osteolytic process.
Gene_expression (produced) of PTHrP in parathyroid associated with hypercalcemia and osteoporosis
8) Confidence 0.75 Published 2000 Journal Cancer Section Abstract Doc Link 10898330 Disease Relevance 1.09 Pain Relevance 0.09
A constitutively active ER-alpha mutation (Tyr537Asn), identified from a human bone metastases, when it was expressed in human breast carcinoma cells, caused increased production of PTHrP.
Gene_expression (production) of PTHrP
9) Confidence 0.75 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.12 Pain Relevance 0
RESULTS: TGFbeta promoted the development and progression of osteolytic bone metastases by inducing tumor production of PTHrP, the effect of which was mediated through the Smad signaling pathway.
Gene_expression (production) of PTHrP
10) Confidence 0.75 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.15 Pain Relevance 0
Transforming growth factor beta (TGFbeta), which is abundant in bone matrix and is released as a consequence of osteoclastic bone resorption, may promote breast carcinoma osteolysis by stimulating PTHrP production by tumor cells.
Gene_expression (production) of PTHrP associated with cancer, breast cancer, osteolysis, hypercalcemia and osteoporosis
11) Confidence 0.75 Published 2000 Journal Cancer Section Abstract Doc Link 10898330 Disease Relevance 1.23 Pain Relevance 0.08
TGFbeta significantly enhanced the ER-alpha-mediated transcriptional activity induced by ER-alpha (Tyr537Asn), and this resulted in further stimulation of PTHrP production.
Gene_expression (production) of PTHrP
12) Confidence 0.75 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.10 Pain Relevance 0
High levels of inflammatory cytokines also potentiate the hypercalcaemic effect of PTHrP, and stimulate further PTHrP production.
Gene_expression (production) of PTHrP associated with inflammation and cytokine
13) Confidence 0.74 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950877 Disease Relevance 1.36 Pain Relevance 0.17
In RA, PTHrP is expressed in the proliferated synovium and such expression is correlated with the inflammatory activity [18,33].
Gene_expression (expressed) of PTHrP in synovium associated with inflammation and rheumatoid arthritis
14) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.61 Pain Relevance 0.27
We previously demonstrated that PTHrP was also expressed in articular chondrocytes [35], and treatment of cultured chondrocytes with PTHrP inhibited chondrocyte differentiation [36].
Gene_expression (expressed) of PTHrP in chondrocytes
15) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.70 Pain Relevance 0.35
However, it is currently recognized that PTHrP is produced by many tissues and is involved in a variety of biological functions by binding to PTH/PTHrP receptor [32].
Gene_expression (produced) of PTHrP
16) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.65 Pain Relevance 0.25
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Gene_expression (expression) of PTHrP
17) Confidence 0.67 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.23 Pain Relevance 0
In rat carotid arteries, the RNase protection assay and in situ hybridization demonstrated that PTHrP mRNA expression increased fourfold to sixfold 1 to 7 days after denudation and continued for 28 days, coincident with downregulation of PTH/PTHrP receptor mRNA expression.
Gene_expression (expression) of PTHrP
18) Confidence 0.67 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8624779 Disease Relevance 0.35 Pain Relevance 0.11
Tumor-produced parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption, is a major mediator of the osteolytic process.
Gene_expression (produced) of hormone-related protein in parathyroid associated with hypercalcemia and osteoporosis
19) Confidence 0.66 Published 2000 Journal Cancer Section Abstract Doc Link 10898330 Disease Relevance 1.08 Pain Relevance 0.09
Another calciotropic hormone that is also produced in the skin, parathyroid hormone-related peptide, is also a potent inhibitor of squamous cell proliferation.
Gene_expression (produced) of parathyroid hormone-related in skin
20) Confidence 0.65 Published 2003 Journal Recent Results Cancer Res. Section Abstract Doc Link 12899511 Disease Relevance 0.64 Pain Relevance 0.20

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