INT1771

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 10.47
Pain Relevance 7.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
plasma 2
heart 2
brain 1
striatum 1
brain stem 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 24 100.00 Very High Very High Very High
amygdala 6 100.00 Very High Very High Very High
Substantia nigra 8 99.82 Very High Very High Very High
Analgesic 14 99.60 Very High Very High Very High
Inflammation 29 98.96 Very High Very High Very High
midbrain 5 98.94 Very High Very High Very High
Enkephalin 26 98.72 Very High Very High Very High
Intracerebroventricular 13 98.66 Very High Very High Very High
substance P 27 98.20 Very High Very High Very High
anesthesia 10 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 257 100.00 Very High Very High Very High
Congenital Anomalies 11 100.00 Very High Very High Very High
Impaired Glucose Tolerance 5 100.00 Very High Very High Very High
Stress 16 99.98 Very High Very High Very High
Hypertension 17 99.72 Very High Very High Very High
Disease 240 99.68 Very High Very High Very High
Pancreatitis 128 99.68 Very High Very High Very High
INFLAMMATION 33 98.96 Very High Very High Very High
Hypoxia 58 98.84 Very High Very High Very High
Myocardial Infarction 102 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Time-dependent increases of 18 and 33% in serum ACE activity were noted after 4 and 8 wk of exposure.
Positive_regulation (increases) of ACE
1) Confidence 0.68 Published 1982 Journal J Toxicol Environ Health Section Abstract Doc Link 6176718 Disease Relevance 0 Pain Relevance 0.09
As reduced neuroprotection is implicated in the pathogenesis of PD [33], one could speculate that the increased ACE activity in subjects with a DD genotype could lower the levels of substance P, making them more susceptible to PD.
Positive_regulation (increased) of ACE associated with disease and substance p
2) Confidence 0.67 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 0.63 Pain Relevance 0.45
Increased ACE activity and intra-myocardial ACE binding sites have been demonstrated in heart failure (Zisman et al 1998).
Positive_regulation (Increased) of ACE in heart associated with myocardial infarction
3) Confidence 0.66 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.88 Pain Relevance 0.16
The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum.
Positive_regulation (increased) of ACE in striatum associated with midbrain
4) Confidence 0.66 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.26
Losartan plus L-NAME treatment caused an increase in plasma ACE activity above control.
Positive_regulation (increase) of ACE in plasma
5) Confidence 0.58 Published 2004 Journal Recept. Channels Section Abstract Doc Link 15989079 Disease Relevance 0.40 Pain Relevance 0.06
The frequency of the homozygote DD genotype of the ACE gene was increased in the PD group (22% in the PD vs 12% in the control group), but the statistical significance was marginal (p = 0.048).
Positive_regulation (increased) of ACE gene associated with disease
6) Confidence 0.49 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 1.00 Pain Relevance 0.03
Over the dose ranges used, the analgesic activities of both ACE and PROP tended to be smaller than those of their respective combinations.
Positive_regulation (smaller) of ACE associated with analgesic
7) Confidence 0.49 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8830199 Disease Relevance 0.07 Pain Relevance 1.00
In situ hybridization and Western blot analysis demonstrated angiotensinogen mRNA and angiotensin converting enzyme (ACE) protein localized to PTs and upregulated in obstructed kidneys, respectively, confirming an increased expression of renal RAS in vivo.
Positive_regulation (demonstrated) of ACE
8) Confidence 0.49 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.27 Pain Relevance 0.10
ACE and RAS activity is known to be enhanced during acute pancreatitis and chronic hypoxia in experimental animals [15,16].
Positive_regulation (enhanced) of ACE associated with hypoxia and pancreatitis
9) Confidence 0.48 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.13 Pain Relevance 0.11
Moreover, ACE is a major pathway for the degradation of bradykinin [8], a peptide of the kinin family involved in the regulation of vascular tone that also participates in the peripheral inflammatory response [9].
Positive_regulation (pathway) of ACE associated with inflammatory response and bradykinin
10) Confidence 0.45 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 1.48 Pain Relevance 0.29
Both circulating and intrinsic pancreatic ACE activity is markedly elevated during acute and chronic inflammation of the pancreas [15,16].
Positive_regulation (elevated) of ACE in pancreas associated with inflammation
11) Confidence 0.44 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.01 Pain Relevance 0.32
Activities of enkephalin- and angiotensin II-forming enzymes (carboxypeptidase H and angiotensin-converting enzyme, ACE) were changed in different brain regions and peripheral tissues of rats with various alcohol motivation.
Positive_regulation (changed) of ACE in brain associated with enkephalin and alcohol
12) Confidence 0.44 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.27
Responses to i.c.v. angiotensin I (AI) were unaffected suggesting lack of inhibition of central angiotensin converting enzyme (ACE).
Positive_regulation (Responses) of angiotensin I
13) Confidence 0.42 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6360696 Disease Relevance 0.10 Pain Relevance 0.43
Both Caf and Bul had a synergism to Ace, but Caf was a stronger synergist in contrast to Bul.
Positive_regulation (synergism) of Ace
14) Confidence 0.41 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749839 Disease Relevance 0 Pain Relevance 0
Striatonigral ACE is undetectable at birth and increases to adult levels by two weeks of age.
Positive_regulation (increases) of ACE
15) Confidence 0.38 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.51
This may be due to activation of prostaglandin synthesis by the accumulation of bradykinin and angiotensin I after captopril.
Positive_regulation (accumulation) of angiotensin I associated with bradykinin
16) Confidence 0.36 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6997055 Disease Relevance 0.09 Pain Relevance 0.09
Chemical stimulation of the substantia nigra with K+ enhanced four times the Met-IR release in the ipsilateral ACE.
Positive_regulation (enhanced) of ACE in ACE associated with substantia nigra and amygdala
17) Confidence 0.36 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3561724 Disease Relevance 0 Pain Relevance 0.49
These results suggest that stress enhances the synaptic activity of the ACe, which stimulates the expression of c-fos.
Positive_regulation (enhances) of ACe in ACe associated with stress
18) Confidence 0.35 Published 1992 Journal Brain Res. Section Abstract Doc Link 1362516 Disease Relevance 0.32 Pain Relevance 0.17
This is supported by studies with enzyme assay showing an increase in ACE activity in the chronically hypoxic rat carotid body comparing with the normoxic control [11].
Positive_regulation (increase) of ACE in carotid body associated with hypoxia
19) Confidence 0.35 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.37 Pain Relevance 0.05
In rats administered a high-salt diet (8% NaCl), the continuous intracerebroventricular infusion of FMRFamide (50 and 200 nmol. kg(-1). d(-1)) for 5 days increased mean arterial pressure, heart rate, urinary excretion of vasopressin and norepinephrine, and mRNAs of renin, angiotensin I-converting enzyme, and angiotensin II type 1 receptor in hypothalamus and brain stem compared with vehicle.
Positive_regulation (increased) of angiotensin I-converting enzyme in brain stem associated with intracerebroventricular
20) Confidence 0.34 Published 2000 Journal Hypertension Section Abstract Doc Link 10642339 Disease Relevance 0.15 Pain Relevance 0.42

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