INT17715

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Context Info
Confidence 0.61
First Reported 1967
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.76
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CELA1) extracellular region (CELA1)
Anatomy Link Frequency
blood 1
CELA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 96.96 Very High Very High Very High
Chronic pancreatitis 5 94.88 High High
backache 2 93.96 High High
Inflammation 1 91.12 High High
alcohol 3 76.68 Quite High
Pain score 1 64.72 Quite High
abdominal pain 2 51.20 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 19 99.74 Very High Very High Very High
Coagulation Disorder 1 99.48 Very High Very High Very High
Cancer 3 97.44 Very High Very High Very High
Ketoacidosis 4 97.12 Very High Very High Very High
Pain 2 96.96 Very High Very High Very High
Hyperlipidemia 4 96.08 Very High Very High Very High
Hypercholesterolemia 1 94.60 High High
Low Back Pain 2 93.96 High High
INFLAMMATION 1 91.12 High High
Recurrence 1 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum elastase-1 level was elevated to 526 ng/dl.
Positive_regulation (elevated) of serum elastase-1
1) Confidence 0.61 Published 2004 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 15549440 Disease Relevance 0.34 Pain Relevance 0.09
Nowadays, there is a test for the determination of fecal elastase-1, by enzymatic reaction (enzyme-linked immunosorbent assay, ELISA), which specifically determines human elastase-1, promoting the pancreatic function evaluation.
Spec (determines) Positive_regulation (determines) of elastase-1
2) Confidence 0.50 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18623102 Disease Relevance 0.39 Pain Relevance 0.09
Furthermore, the levels of pancreatic enzyme including serum amylase (770 U/l) and elastase I (2721 ng/dl) were elevated.
Positive_regulation (elevated) of elastase I
3) Confidence 0.26 Published 1991 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 1937346 Disease Relevance 1.30 Pain Relevance 0.16
Only negligible activity was detected for elastase 1 or amylase in the stone extracts.
Positive_regulation (detected) of elastase 1
4) Confidence 0.24 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8200269 Disease Relevance 0.38 Pain Relevance 0.08
For example, in the higher animals, enzymes for activation of zymogens (trypsin), for digestion of dietary proteins (trypsin, chymotrypsin, elastase), for blood clotting (thrombin), for clot lysis (plasmin), and for sensing pain (kallikrein) all appear to use the same mechanism and to have evolved from the same ancestral gene by the process of gene duplication and subsequent divergent evolution.
Positive_regulation (activation) of elastase in blood associated with pain and coagulation disorder
5) Confidence 0.01 Published 1967 Journal Science Section Abstract Doc Link 4862530 Disease Relevance 0.20 Pain Relevance 0.10
Serial measurements of the three enzymes in acute pancreatitis showed that elastase remained elevated longer than amylase and pancreatic isoamylase.
Positive_regulation (elevated) of elastase associated with pancreatitis
6) Confidence 0.01 Published 1987 Journal Br J Surg Section Abstract Doc Link 2435358 Disease Relevance 0.72 Pain Relevance 0.26
Trypsinogen and elastase secreted into pancreatic juice were upregulated after a protein-deficient diet relative to a control diet.
Positive_regulation (upregulated) of elastase
7) Confidence 0.00 Published 2000 Journal Pancreas Section Abstract Doc Link 10975713 Disease Relevance 0.23 Pain Relevance 0.11
Earlier studies using a radioimmunoassay reported a prolonged elevation of serum elastase as compared to other pancreatic enzymes in acute pancreatitis.
Positive_regulation (elevation) of elastase associated with pancreatitis
8) Confidence 0.00 Published 1999 Journal Z Gastroenterol Section Abstract Doc Link 10494604 Disease Relevance 0.21 Pain Relevance 0.12

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