INT17716

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 4.38
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh2) oxidoreductase activity (Aldh2)
Aldh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 51 99.38 Very High Very High Very High
headache 138 98.32 Very High Very High Very High
addiction 30 94.28 High High
tolerance 102 92.84 High High
Chronic pancreatitis 4 90.80 High High
Angina 9 87.20 High High
Spinal cord 6 74.28 Quite High
Cancer pain 41 71.64 Quite High
peptic ulcer disease 1 61.60 Quite High
Pain 86 56.28 Quite High
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 1 99.60 Very High Very High Very High
Headache 154 98.32 Very High Very High Very High
Cancer 80 96.24 Very High Very High Very High
Breast Cancer 18 95.28 Very High Very High Very High
Increased Venous Pressure Under Development 25 94.92 High High
Cirrhosis 4 92.64 High High
Pancreatitis 4 90.80 High High
Prostate Cancer 3 90.00 High High
Bladder Cancer 5 89.20 High High
Alcohol Addiction 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the mitochondrial aldehyde dehydrogenase (ALDH2) is inhibited in GTN-tolerant tissues and produces NO2- from GTN, which is proposed to be converted to NO within mitochondria.
Gene_expression (produces) of ALDH2
1) Confidence 0.77 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573760 Disease Relevance 0.17 Pain Relevance 0.29
Materials—Recombinant human ALDH2 was expressed in and
purified from Escherichia coli
(16). 
Gene_expression (expressed) of ALDH2
2) Confidence 0.71 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.21
However, the mitochondrial aldehyde dehydrogenase (ALDH2) is inhibited in GTN-tolerant tissues and produces NO2- from GTN, which is proposed to be converted to NO within mitochondria.
Gene_expression (produces) of mitochondrial aldehyde dehydrogenase
3) Confidence 0.67 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573760 Disease Relevance 0.18 Pain Relevance 0.30
Immunoblot analysis indicated that the majority of vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of GTN by ALDH2 plays a minor role in the overall vascular biotransformation of GTN by this enzyme.
Gene_expression (biotransformation) of ALDH2
4) Confidence 0.67 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573760 Disease Relevance 0.26 Pain Relevance 0.13
g/ml ALDH2 for
the dehydrogenase activity; 50 mm NaPi (pH 7.5), 0.1
mm p-NPA, 10 mm MgCl2, and 1.5
?
Gene_expression (1.5) of ALDH2
5) Confidence 0.61 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
g/ml ALDH2 for
the dehydrogenase activity; 50 mm NaPi (pH 7.5), 0.1
mm p-NPA, 10 mm MgCl2, and 1.5
?
Gene_expression (activity) of ALDH2
6) Confidence 0.61 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
In addition, disulfiram, an aldehyde dehydrogenase inhibitor, given with ethanol, causes symptoms similar to those seen in individuals expressing functionally inactive ALDH-2.
Neg (inactive) Gene_expression (expressing) of ALDH-2
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013144 Disease Relevance 0.84 Pain Relevance 0.69
One major unresolved question
concerns the identity of the physiological reductant, because ALDH2-catalyzed
GTN reduction is supported by the non-physiological thiol dithiothreitol (DTT)
but not by glutathione (GSH), the most abundant physiological low-molecular
weight thiol. 
Gene_expression (reduction) of ALDH2-catalyzed
8) Confidence 0.53 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.12 Pain Relevance 0.05
Interestingly, activation
of sGC by GTN has been accomplished in the presence of purified mitochondrial
ALDH2, suggesting that the ALDH2-catalyzed decomposition of GTN yields NO
(12); the physiological
relevance of this observation is not clear yet.
Gene_expression (decomposition) of ALDH2-catalyzed
9) Confidence 0.53 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.09 Pain Relevance 0.18
Importantly, ALDH2-catalyzed GTN
reduction was partly inactivated by preincubation with GTN, suggesting that
the inactivation of GTN reduction is also partly irreversible. 
Gene_expression (reduction) of ALDH2-catalyzed
10) Confidence 0.53 Published 2008 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
This suggests that the headache experienced after the combination of ethanol and disulfiram and in individuals who lack functional ALDH-2 is not due to the same mechanism as the hangover headache experienced in the absence of disulfiram.
Neg (lack) Gene_expression (lack) of ALDH-2 associated with headache
11) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013144 Disease Relevance 0.58 Pain Relevance 0.43
The expression and activity of formaldehyde generating enzymes, such as lysine-specific demethylase 1 (LSD1) [25], [26], semicarbazide-sensitive amine oxidase (SSAO) [27], [28] and cytochrome P-450 [29], [30], formaldehyde degrading enzymes, such as aldehyde dehydrogenase 2 (ALDH2) and class III alcohol dehydrogenase (ADH3) [31], [32], are considered to have critical roles in the pathogenesis of breast cancer.
Gene_expression (expression) of ALDH2 associated with breast cancer and alcohol
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 1.25 Pain Relevance 0.43
The present study demonstrated that the ADH1B -2 allele frequency among Uzbeks was closer to that among Caucasians than East Asians, some Uzbeks also demonstrating the ALDH2 -2 allele.
Gene_expression (demonstrating) of ALDH2 -2 allele
13) Confidence 0.25 Published 2009 Journal Asian Pac. J. Cancer Prev. Section Abstract Doc Link 19469618 Disease Relevance 0.19 Pain Relevance 0.10
Polymorphisms have been observed at two of the five loci encoding alcohol dehydrogenase subunits: ADH2 (producing three beta subunits) and ADH3 (producing two tau subunits) and also at the locus encoding the metabolically important form of aldehyde dehydrogenase, ALDH2.
Gene_expression (producing) of ALDH2 associated with alcohol
14) Confidence 0.14 Published 1991 Journal Hepatology Section Abstract Doc Link 1937384 Disease Relevance 0.35 Pain Relevance 0.40
Polymorphisms have been observed at two of the five loci encoding alcohol dehydrogenase subunits: ADH2 (producing three beta subunits) and ADH3 (producing two tau subunits) and also at the locus encoding the metabolically important form of aldehyde dehydrogenase, ALDH2.
Gene_expression (producing) of ALDH2 associated with alcohol
15) Confidence 0.14 Published 1991 Journal Hepatology Section Abstract Doc Link 1937384 Disease Relevance 0.35 Pain Relevance 0.40

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