INT177252

Context Info Confidence 0.45 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

endoplasmic reticulum (SV2A, CYP2B6) small molecule metabolic process (CYP2B6) transmembrane transporter activity (SV2A) cytoplasm (SV2A)

Anatomy Link Frequency CAR 1 SV2A (Homo sapiens) CYP2B6 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 2 44.76 Paracetamol 1 5.00 Kinase C 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 2 5.00 Liver Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, CAR(SV3) significantly transactivated the CYP2B6 and MDR1 reporter genes 3-fold and 7-fold, respectively, whereas the CYP3A4 reporter gene was not significantly activated (Fig. 4).

SV3 Positive_regulation (transactivated) of CYP2B6 in CAR

1) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

General Comments

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