INT177269

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CXADR, NR1H4) nucleoplasm (NR1H4) mitochondrion organization (CXADR)
protein complex (CXADR) cytoplasm (CXADR) extracellular space (CXADR)
Anatomy Link Frequency
CAR 11
CXADR (Homo sapiens)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 22 99.32 Very High Very High Very High
Kinase C 11 98.84 Very High Very High Very High
Paracetamol 11 77.80 Quite High
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 22 5.00 Very Low Very Low Very Low
Liver Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Usually, CAR binds to DNA as a heterodimer with RXR.
CAR Binding (binds) of RXR in CAR
1) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.10
Fig. 3A shows that the LBD of reference CAR(SV1) and of CAR(SV3) did interact constitutively with the LBD of RXR?.
CAR Binding (interact) of RXR in CAR
2) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
We showed that none of the CAR protein variants bind to DNA as a heterodimer with RXR?.
CAR Binding (bind) of RXR in CAR
3) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.05
Treatment with the human CAR-specific agonist CITCO [10] did not influence the interaction of any CAR isoform with RXR?
CAR Neg (not) Binding (interaction) of RXR in CAR associated with agonist
4) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.05
Fig. 3A shows that the LBD of reference CAR(SV1) and of CAR(SV3) did interact constitutively with the LBD of RXR?.
CAR Binding (interact) of RXR in CAR
5) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
To transactivate the expression of its target genes, CAR has to bind to its response elements as a heterodimer with RXR?.
CAR Binding (heterodimer) of RXR in CAR
6) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.03
To transactivate the expression of its target genes, CAR has to bind to its response elements as a heterodimer with RXR?.
CAR Binding (bind) of RXR in CAR
7) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.03
Furthermore, CAR(SV3) transactivation activity and interaction with RXR?
CAR Binding (interaction) of RXR in CAR
8) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.03
Usually, CAR binds to DNA as a heterodimer with RXR.
CAR Binding (heterodimer) of RXR in CAR
9) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.10
and CAR(SV1) was about 10-fold stronger than interaction between RXR?
CAR Binding (interaction) of RXR in CAR
10) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.05
We showed that none of the CAR protein variants bind to DNA as a heterodimer with RXR?.
CAR Binding (heterodimer) of RXR in CAR
11) Confidence 0.03 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.05

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