INT177301

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 14 50.00 Quite Low
agonist 3 50.00 Quite Low
Inflammatory stimuli 1 9.52 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 25 94.80 High High
Neuroblastoma 6 57.20 Quite High
INFLAMMATION 10 9.20 Low Low
Repression 7 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low
Chondrosarcoma 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with the idea that treatment with both ligands might increase the binding of RXR:PPAR?
Spec (might) Positive_regulation (increase) of RXR Spec (might) Binding (binding) of
1) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
Positive_regulation (requirements) of RXR Binding (heterodimer) of associated with rheumatoid arthritis
2) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
Having bound a ligand seems to induce a sufficiently stabilized active conformation so that heterodimerization with RXR?
Positive_regulation (induce) of RXR Binding (heterodimerization) of
3) Confidence 0.04 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

General Comments

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