INT177305

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 1.10
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXADR) extracellular region (CXADR) cell adhesion (CXADR)
mitochondrion organization (CXADR) plasma membrane (CXADR) nucleus (CXADR)
Anatomy Link Frequency
CAR 10
kidney 7
Caco-2 2
liver 1
muscle 1
CXADR (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 6 92.16 High High
Substantia nigra 108 91.72 High High
anesthesia 6 91.28 High High
Dopamine 108 50.44 Quite High
Central nervous system 54 43.60 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
midbrain 18 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 138 97.76 Very High Very High Very High
Cytomegalovirus Infection 18 44.64 Quite Low
Disease 6 43.96 Quite Low
Parkinson's Disease 90 5.00 Very Low Very Low Very Low
Infection 24 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Colon Cancer 12 5.00 Very Low Very Low Very Low
Hypokinesia 6 5.00 Very Low Very Low Very Low
Rabies Virus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For Western blot analysis of CAR isoforms, COS1 cells were co-transfected with the respective expression plasmids and ?
Positive_regulation (transfected) of Gene_expression (transfected) of CAR in CAR
1) Confidence 0.48 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Correct splicing of exon 8 to exon 9 is restricted to only a few tissues, among them liver and small intestine for which CAR function has been demonstrated, and is associated with the induction of CAR expression during differentiation of intestinal cells.


Positive_regulation (induction) of Gene_expression (expression) of CAR in CAR
2) Confidence 0.45 Published 2004 Journal Nucl Recept Section Abstract Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
As enterocytic differentiation of Caco-2 TC7 cells took place when the cell culture reached confluence [18], we assumed that CAR expression was induced by differentiation.
Positive_regulation (induced) of Gene_expression (expression) of CAR in Caco-2
3) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Since we could demonstrate tissue-specific alternative splicing of CAR, it was of interest to see whether alternative splicing may also be associated with the induction of CAR expression by differentiation.
Positive_regulation (induction) of Gene_expression (expression) of CAR in CAR
4) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Simultaneously, CAR expression was strongly induced.
Positive_regulation (induced) of Gene_expression (expression) of CAR in CAR
5) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Thus, the strong induction of CAR expression by enterocytic differentiation was also associated with a switch in alternative splicing.


Positive_regulation (induction) of Gene_expression (expression) of CAR in CAR
6) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in lungs Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
8) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in brain Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
9) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in heart Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
10) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in liver Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
11) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of in muscle Gene_expression (expressed) of hCAR in kidney associated with targeted disruption
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25

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