INT177310

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (SV2A) endoplasmic reticulum (SV2A) cytoplasm (SV2A)
Anatomy Link Frequency
CAR 6
SV2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 72.52 Quite High
agonist 6 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 6 5.00 Very Low Very Low Very Low
Liver Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
causes the loss of constitutive coactivator interaction of CAR(SV2) and of the other isoforms, as they all are compromised in heterodimerization with RXR?.
Negative_regulation (loss) of SV2 Binding (interaction) of in CAR
1) Confidence 0.54 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
In agreement with their impaired DNA binding, CAR protein variants SV2, SV4, SV5 and SV6 did not transactivate significantly either reporter gene construct tested.
Negative_regulation (impaired) of SV5 Binding (binding) of in CAR
2) Confidence 0.40 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
Likewise CAR(SV5) is probably impaired in ligand binding, as homology modeling of the CAR LBD has shown that residues of helices H10/11 and H12 should participate in the ligand binding cavity [20].
Negative_regulation (impaired) of SV5 Binding (binding) of in CAR
3) Confidence 0.34 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

General Comments

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