INT177310

Context Info Confidence 0.54 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0.04

transmembrane transporter activity (SV2A) endoplasmic reticulum (SV2A) cytoplasm (SV2A)

Anatomy Link Frequency CAR 6 SV2A (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 3 72.52 agonist 6 5.00 Paracetamol 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Colon Cancer 6 5.00 Liver Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

causes the loss of constitutive coactivator interaction of CAR(SV2) and of the other isoforms, as they all are compromised in heterodimerization with RXR?.

Negative_regulation (loss) of SV2 Binding (interaction) of in CAR

1) Confidence 0.54 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

In agreement with their impaired DNA binding, CAR protein variants SV2, SV4, SV5 and SV6 did not transactivate significantly either reporter gene construct tested.

Negative_regulation (impaired) of SV5 Binding (binding) of in CAR

2) Confidence 0.40 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04

Likewise CAR(SV5) is probably impaired in ligand binding, as homology modeling of the CAR LBD has shown that residues of helices H10/11 and H12 should participate in the ligand binding cavity [20].

Negative_regulation (impaired) of SV5 Binding (binding) of in CAR

3) Confidence 0.34 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

General Comments

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