INT177312

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
Anatomy Link Frequency
Caco-2 2
osteoclast 2
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 8.28 Low Low
Inflammation 6 7.88 Low Low
agonist 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 8 91.64 High High
Rickets 3 87.28 High High
Infection 32 77.72 Quite High
Immunodeficiency 2 77.08 Quite High
Osteoporosis 15 63.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 64 50.00 Quite Low
Aging 12 50.00 Quite Low
Parkinson's Disease 3 34.08 Quite Low
INFLAMMATION 7 7.88 Low Low
Phosphate Metabolism Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of Gnas gene expression may result in less mitogen-activated protein kinase/extracellular signal-regulated kinase signaling and ultimately a reduction in osteoclast proliferation and actin filament formation, resulting in decreased bone resorption.
Negative_regulation (downregulation) of Gene_expression (expression) of Gnas gene in osteoclast associated with hypercalcemia
1) Confidence 0.05 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.46 Pain Relevance 0
However, Caco-2 cells grown for 15 days post confluence showed a strong expression of transcripts without and a markedly reduced expression of transcript with the deletion in exon 9 (Fig. 7B).
Negative_regulation (reduced) of Gene_expression (expression) of exon in Caco-2
2) Confidence 0.01 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0

General Comments

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