INT177316

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 1.05
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXADR) extracellular region (CXADR) cell adhesion (CXADR)
mitochondrion organization (CXADR) plasma membrane (CXADR) nucleus (CXADR)
Anatomy Link Frequency
CAR 5
neuronal 1
nucleus 1
CXADR (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 36 99.68 Very High Very High Very High
Paracetamol 6 99.32 Very High Very High Very High
Central nervous system 20 95.96 Very High Very High Very High
imagery 12 91.84 High High
agonist 14 83.88 Quite High
Kinase C 6 51.04 Quite High
midbrain 6 50.04 Quite High
Dopamine 36 50.00 Quite Low
addiction 4 38.60 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.44 Very High Very High Very High
Parkinson's Disease 30 98.36 Very High Very High Very High
Neurodegenerative Disease 6 97.20 Very High Very High Very High
Cancer 6 77.52 Quite High
Rabies Virus Infection 2 76.88 Quite High
Adhesions 2 59.76 Quite High
Disease 22 5.00 Very Low Very Low Very Low
Colon Cancer 16 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with inducers, among them bilirubin, phenobarbital and acetaminophen [3,7,8], then stimulates nuclear translocation of CAR by a poorly understood mechanism.
Localization (translocation) of CAR in CAR associated with paracetamol
1) Confidence 0.77 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.10
Vitamin D receptor and pregnane X receptor, which are the closest relatives of CAR, exhibit extensive alternative splicing [13,14].
Localization (relatives) of CAR in CAR
2) Confidence 0.72 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
CITCO did not influence the interaction properties of CAR isoforms SV3, SV4, SV5 and SV6.
Localization (properties) of CAR in CAR
3) Confidence 0.72 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Once translocated to the nucleus, CAR constitutively activates target genes.
Localization (translocated) of CAR in CAR
4) Confidence 0.67 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.09
Unexpectedly, even CAR(SV5) which lacks the last 42 residues did not show decreased nuclear localization.
Localization (localization) of CAR in CAR
5) Confidence 0.63 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.03
Once translocated to the nucleus, CAR constitutively activates target genes.
Localization (translocated) of CAR in nucleus
6) Confidence 0.23 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.09
The subcellular localization of hCAR(sv5) is similar to that of hCAR [Arnold et al., 2004].
Localization (localization) of hCAR
7) Confidence 0.05 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
The subcellular localization of hCAR(sv5) is similar to that of hCAR [Arnold et al., 2004].
Localization (localization) of hCAR
8) Confidence 0.04 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2716050 Disease Relevance 0 Pain Relevance 0
We were able to perform immunohistochemistry for hCAR in the vMB to identify at a cellular level the localization of hCAR in this region, allowing us to understand the role this exogenous protein plays in expanding Ad transduction, and better understand the utility of tropism-modified ADs.
Localization (localization) of hCAR
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.42 Pain Relevance 0.14
We used immunohistochemical methods to localize hCAR in the SN of transgenic animals, and found that the majority of the hCAR protein localizes to post-synaptic structures in the neuropil and along the margins of neurons while relatively little is found within neuronal or glial perikarya.
Localization (localize) of hCAR in neuronal associated with targeted disruption and substantia nigra
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.64 Pain Relevance 0.16

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