INT177328

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 4.29
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXADR) extracellular region (CXADR) cell adhesion (CXADR)
mitochondrion organization (CXADR) plasma membrane (CXADR) nucleus (CXADR)
Anatomy Link Frequency
CAR 9
liver 1
muscle 1
striatum 1
brain 1
CXADR (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal dorsal horn 76 92.56 High High
Substantia nigra 126 91.72 High High
Calcitonin gene-related peptide 10 91.72 High High
imagery 30 91.68 High High
isoflurane 8 90.88 High High
anesthesia 8 90.00 High High
Somatostatin 4 86.52 High High
nMDA receptor 8 85.60 High High
peripheral neuropathy 2 84.88 Quite High
Inflammation 70 80.32 Quite High
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 23 100.00 Very High Very High Very High
Sprains And Strains 10 99.90 Very High Very High Very High
Breast Cancer 12 99.70 Very High Very High Very High
Cancer 57 99.52 Very High Very High Very High
Targeted Disruption 161 97.76 Very High Very High Very High
Injury 11 91.28 High High
Syndrome 6 88.04 High High
Peripheral Neuropathy 2 84.88 Quite High
INFLAMMATION 70 80.32 Quite High
Myoclonus 1 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene-specific transactivation activity of isoform CAR(SV3)
Positive_regulation (transactivation) of CAR in CAR
1) Confidence 0.48 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
Thus the ratio of CAR(SV2) and reference CAR(SV1) may determine CAR-dependent activation by inducers which also act as ligands.
Spec (determine) Positive_regulation (activation) of CAR-dependent in CAR
2) Confidence 0.48 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
The difference in the type of binding site may explain the observed gene-specific transactivation activity of CAR(SV3).
Positive_regulation (transactivation) of CAR in CAR
3) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
More recently, endogenous compounds, like estrogens and bilirubin have been shown to activate CAR [2,3].
Positive_regulation (activate) of CAR in CAR
4) Confidence 0.45 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.07
Reactivity to RAs of sera in patients with breast cancer could also be present in cases without clinical signs of CAR.
Positive_regulation (present) of CAR in CAR associated with breast cancer and ocular toxicity (including many sub-types)
5) Confidence 0.32 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 1.76 Pain Relevance 0.04
Since Ad5.PTDtat showed more profound infectivity enhancement for low-CAR expressing tumor cells in vitro, we assessed the in vivo gene delivery efficacy of the Ad5 vectors using tumor models established with low-CAR containing U118MG cells.
Positive_regulation (enhancement) of low-CAR in CAR associated with cancer
6) Confidence 0.27 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.60 Pain Relevance 0.03
On the other hand, the divergence between isolates of the two lineages indicates that different strains are circulating in some countries, such as CAR, Senegal, and Kenya.
Positive_regulation (circulating) of CAR in CAR associated with sprains and strains
7) Confidence 0.04 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2732512 Disease Relevance 0.32 Pain Relevance 0
We found that in the hCAR animals, there was an approximately 100-fold increase in the number of anterogradely labeled fibers in the striatum (Percentage of total area occupied, mean ± SEM of wt ?
Positive_regulation (increase) of hCAR in striatum
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.15 Pain Relevance 0.08
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in kidney associated with targeted disruption
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Finally, one gene (encoding NK2 tachykinin receptor), while also being up-regulated in the CAR-P3 and CAR-12 groups, showed a significantly weaker increase in CAR-P3 rats as compared to that in CAR-P12 animals (by 0.7 fold).
Positive_regulation (increase) of CAR in CAR
10) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.08 Pain Relevance 0.18
In addition to bilateral changes, comparison of the CONT and CAR-P3 groups revealed neonatal CAR injection-induced up-regulation (by 1.9–3.2 fold) of seven genes (coding for GABAB1f, GABAB1b, 5-HT1b serotonergic, NtsR1 neurotensin and H1 histamine receptors, GAG67, and preprocholecystokinin) confined to the left LDH ipsilateral to the neonatal injury (Table 2).
Positive_regulation (up-regulation) of CAR in CAR associated with spinal dorsal horn and injury
11) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.28 Pain Relevance 0.32
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in brain associated with targeted disruption
12) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in liver associated with targeted disruption
13) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in muscle associated with targeted disruption
14) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in heart associated with targeted disruption
15) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Positive_regulation (allowing) of hCAR in lungs associated with targeted disruption
16) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.25

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