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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.44
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
macrophages 1
fat 1
muscle 1
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
Central nervous system 24 98.20 Very High Very High Very High
fibrosis 10 93.32 High High
agonist 2 86.52 High High
ischemia 2 76.56 Quite High
depression 12 73.16 Quite High
Pain 3 70.60 Quite High
Peripheral nervous system 2 64.24 Quite High
carbamazepine 1 50.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Apoptosis 6 99.84 Very High Very High Very High
Frailty 5 99.74 Very High Very High Very High
Obesity 10 98.28 Very High Very High Very High
Prostate Cancer 98 96.92 Very High Very High Very High
Fibrosis 2 93.32 High High
Hypersensitivity 3 91.20 High High
Viral Meningitis 2 90.48 High High
Rickets 10 89.40 High High
Muscle Disease 8 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed no direct relationship of the VDR FokI or BsmI polymorphism with risk of total, nonaggressive, and aggressive prostate cancer (Table 3), and the associations did not differ by age at diagnosis.
Localization (relationship) of VDR associated with prostate cancer
1) Confidence 0.73 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.39 Pain Relevance 0
Finally, VDR-dependent immunosuppressive effects, including increased concentrations of inflammatory cytokines, macrophages, polynuclears, as well as their sensitization to apoptotic signals, were described in the CNS [70].
Localization (sensitization) of VDR in macrophages associated with inflammation, central nervous system, apoptosis and cytokine
2) Confidence 0.43 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 1.14 Pain Relevance 0.29
It has also been shown predominantly type II muscle fibres atrophy [50], while vitamin D repletion instead leads to an increase in relative fibres composition and in fibres area of type IIa muscle fibres [51,52].
Localization (repletion) of vitamin D in muscle associated with frailty
3) Confidence 0.37 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2959005 Disease Relevance 1.05 Pain Relevance 0.20
One explanation was that the subcutaneous fat, which is known to store vitamin D, sequestered more of the cutaneous synthesized vitamin D, which results in less release of vitamin D from the skin into the circulation in the obese subject than non-obese subject [45].

Localization (release) of vitamin D in fat associated with obesity
4) Confidence 0.35 Published 2010 Journal Nutr J Section Body Doc Link PMC3019131 Disease Relevance 0.79 Pain Relevance 0.03
Vitamin D receptor and pregnane X receptor, which are the closest relatives of CAR, exhibit extensive alternative splicing [13,14].
Localization (relatives) of Vitamin D receptor in CAR
5) Confidence 0.19 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
The only patients who did not improve during the second winter were those who had been maintained on the higher dose of vitamin D for the 12 months leading up to December 2002, and whose wellbeing score had already improved during Study 1.
Localization (dose) of vitamin D
6) Confidence 0.06 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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