INT177342

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.66
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SRGN) extracellular region (SRGN) Golgi apparatus (SRGN)
Anatomy Link Frequency
plasma 1
SRGN (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 98 76.80 Quite High
palliative 2 28.72 Quite Low
Inflammation 1 12.00 Low Low
cva 1 11.32 Low Low
Onset of action 18 5.00 Very Low Very Low Very Low
Clonidine 6 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 51 100.00 Very High Very High Very High
Disease 62 98.92 Very High Very High Very High
Diabetes Mellitus 865 98.64 Very High Very High Very High
Injury 5 98.24 Very High Very High Very High
Optic Disorders 16 95.36 Very High Very High Very High
Hypoglycemia 550 94.56 High High
Myocardial Infarction 20 91.16 High High
Stroke 16 90.00 High High
Hyperlipidemia 23 87.36 High High
Hypertension 6 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, a change in the diagnostic criteria of glaucoma has been promoted such that glaucoma diagnosis may be made before the old prerequisites’ functional criteria of standard automatic perimetry visual field (SAP- VF) loss are apparent, namely ‘preperimetric glaucoma' (PPG).
Negative_regulation (loss) of PPG associated with glaucoma
1) Confidence 0.28 Published 2010 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2928913 Disease Relevance 1.21 Pain Relevance 0
Compared to NPH twice daily, biphasic insulin aspart twice daily is as effective in reducing HbA1c and more effective in reducing PPG.
Negative_regulation (reducing) of PPG
2) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.13 Pain Relevance 0
In a systematic review of 21 published clinical trials comparing the efficacy of biphasic insulin aspart 70/30 with other treatment strategies in patients with type 2 diabetes, Halimi et al found that biphasic insulin aspart 70/30 twice daily reduced PPG to a greater extent than biphasic human insulin 70/30 twice daily, NPH twice daily, or insulin glargine once daily.
Negative_regulation (reduced) of PPG associated with diabetes mellitus
3) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.39 Pain Relevance 0
Significantly fewer PPG excursions were observed after biphasic insulin aspart 70/30 compared to after biphasic insulin lispro 75/25 and to after biphasic human insulin 70/30, which suggests that biphasic insulin aspart more effectively reduces PPG compared to other biphasic insulins (Figure 2).
Negative_regulation (reduces) of PPG
4) Confidence 0.19 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.20 Pain Relevance 0
Biphasic insulin aspart reduces PPG excursions, and is effective in achieving HbA1c goals.
Negative_regulation (reduces) of PPG
5) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.20 Pain Relevance 0
Thus, in patients with type 2 diabetes, biphasic insulin aspart twice daily was as effective in reducing HbA1c and more effective in reducing PPG compared to NPH twice daily.
Negative_regulation (reducing) of PPG associated with diabetes mellitus
6) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.28 Pain Relevance 0
Greater reductions in PPG were reported with exenatide (morning meal p < 0.001, midday meal p = 0.002, and evening meal p < 0.001).
Negative_regulation (reductions) of PPG
7) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.07 Pain Relevance 0
assessment), increases in postprandial insulin and C-peptide, and decreases in postprandial glucagon vs TZD monotherapy.6 In conclusion, saxagliptin plus TZD demonstrated statistically significant reductions in HbA1c, FPG, and PPG compared with TZD alone in patients inadequately controlled on TZD monotherapy.6

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Negative_regulation (reductions) of PPG
8) Confidence 0.14 Published 2010 Journal Core Evidence Section Body Doc Link PMC2963920 Disease Relevance 0 Pain Relevance 0
Thus, the assumption in the model that reducing PPG levels will reduce the risk of macrovascular disease remains to be proven conclusively[3,47].
Negative_regulation (reducing) of PPG associated with disease
9) Confidence 0.09 Published 2004 Journal Cost Eff Resour Alloc Section Body Doc Link PMC406422 Disease Relevance 1.13 Pain Relevance 0
Fasting plasma glucose and PPG concentrations were also significantly reduced after 3 and 6 months’ treatment with BIAsp 30, again, irrespective of type of previous basal insulin treatment (Table 2).
Negative_regulation (reduced) of PPG in plasma
10) Confidence 0.09 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2438599 Disease Relevance 0.31 Pain Relevance 0
However, the reduction in HbA1c and PPG levels when treating patients with type 2 diabetes with a combination of nateglinide and metformin has the potential to translate into reduced complication rates.
Negative_regulation (reduction) of PPG associated with diabetes mellitus
11) Confidence 0.07 Published 2004 Journal Cost Eff Resour Alloc Section Body Doc Link PMC406422 Disease Relevance 0.24 Pain Relevance 0
Thus, the assumption in the model that reducing PPG levels will reduce the risk of macrovascular disease remains to be proven conclusively[3,47].
Negative_regulation (reduce) of PPG associated with disease
12) Confidence 0.07 Published 2004 Journal Cost Eff Resour Alloc Section Body Doc Link PMC406422 Disease Relevance 1.13 Pain Relevance 0
However, the critical micelle concentration (CMC) of Pluronic F127 is very high due to weak hydrophobicity of PPG block.
Negative_regulation (block) of PPG
13) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2920883 Disease Relevance 0.16 Pain Relevance 0
The reduction in 1-h PPG was similar and that in 2h-PPG levels was significantly greater in the vildagliptin group compared with that in the voglibose group (Figure 4B, p < 0.001). ?
Negative_regulation (reduction) of PPG
14) Confidence 0.01 Published 2010 Journal Diabetes, Obesity & Metabolism Section Body Doc Link PMC2916214 Disease Relevance 0.20 Pain Relevance 0
Exenatide 2 mg once weekly showed significantly greater reduction in PPG than did sitagliptin (p < 0.05) but not compared to pioglitazone[37].
Negative_regulation (reduction) of PPG
15) Confidence 0.01 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3017518 Disease Relevance 0 Pain Relevance 0.04

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