INT177347

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gli2) anatomical structure formation involved in morphogenesis (Gli2) intracellular (Gli2)
cilium (Gli2) DNA binding (Gli2) cytoplasm (Gli2)
Anatomy Link Frequency
lung 4
Gli2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 99.96 Very High Very High Very High
Inflammation 74 95.60 Very High Very High Very High
cINOD 8 80.68 Quite High
Potency 10 79.60 Quite High
imagery 1 21.60 Low Low
Pain 1 7.92 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.48 Very High Very High Very High
Chondroma 41 99.02 Very High Very High Very High
INFLAMMATION 66 95.60 Very High Very High Very High
Enchondromatosis 56 94.88 High High
Cancer 10 92.44 High High
Asthma 42 88.88 High High
Hypersensitivity 6 86.72 High High
Pneumonia 18 74.36 Quite High
Cleidocranial Dysplasia 2 68.88 Quite High
Chondrosarcoma 12 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because regulation of Ihh by PTHrP was found to be lost in these enchondromas, additional transgenic mice were generated that overexpress the Hedgehog (Hh) transcriptional regulator, Gli2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of Gli2 associated with targeted disruption and chondroma
1) Confidence 0.25 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.51 Pain Relevance 0
In addition, in vitro restimulation of lung homogenates with ovalbumin induced an increased production of T-helper 2 cytokines in female versus male mice.
Positive_regulation (induced) of Gene_expression (production) of T-helper 2 in lung associated with cytokine
2) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.55 Pain Relevance 0.35
In addition, in vitro restimulation of lung homogenates with ovalbumin induced an increased production of T-helper 2 cytokines in female versus male mice.
Positive_regulation (increased) of Gene_expression (production) of T-helper 2 in lung associated with cytokine
3) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.55 Pain Relevance 0.35

General Comments

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