INT17736

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 111
Total Number 115
Disease Relevance 40.68
Pain Relevance 36.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
cortex 12
amygdala 7
neurons 6
tail 3
striatum 3
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1140 100.00 Very High Very High Very High
Hippocampus 951 100.00 Very High Very High Very High
Nucleus accumbens 765 100.00 Very High Very High Very High
Pyramidal cell 663 100.00 Very High Very High Very High
noradrenaline 387 100.00 Very High Very High Very High
long-term potentiation 278 100.00 Very High Very High Very High
depression 184 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
amygdala 1356 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 206 100.00 Very High Very High Very High
Nervous System Injury 5 100.00 Very High Very High Very High
Urological Neuroanatomy 148 99.96 Very High Very High Very High
Anxiety Disorder 1732 99.88 Very High Very High Very High
Pain 107 99.80 Very High Very High Very High
Stress 2008 99.72 Very High Very High Very High
Schizophrenia 226 99.60 Very High Very High Very High
Post-traumatic Stress Disorder 342 99.54 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 124 99.54 Very High Very High Very High
Li-fraumeni Syndrome 84 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study evaluated two inhibitors of endopeptidase 24.15, N-[1-(RS)-carboxy-3-phenyl-propyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB), and N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-D-Ala-Phe-p-aminobenzoate (cFP-A(D)AF-pAB), for antinociception on the tail-flick and jump tests in rats following intracerebroventricular administration relative to an inhibitor of endopeptidase 24.11, N-(1-(RS)-carboxy-3-phenylpropyl]-Phe-p-aminobenzoate (cFP-F-pAB). cFP-AAF-pAB, cFP-A(D)AF-pAB and cFP-F-pAB produced equipotent dose-dependent (25-250 nmol) and time-dependent (5-7 h) antinociception with larger effects on the jump (49-51% increase) relative to the tail-flick (28-41% increase) test.
Gene_expression (produced) of cFP in tail associated with antinociception, tail-flick and intracerebroventricular
1) Confidence 0.65 Published 1991 Journal Int. J. Neurosci. Section Abstract Doc Link 1938129 Disease Relevance 0 Pain Relevance 0.74
The present study evaluated two inhibitors of endopeptidase 24.15, N-[1-(RS)-carboxy-3-phenyl-propyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB), and N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-D-Ala-Phe-p-aminobenzoate (cFP-A(D)AF-pAB), for antinociception on the tail-flick and jump tests in rats following intracerebroventricular administration relative to an inhibitor of endopeptidase 24.11, N-(1-(RS)-carboxy-3-phenylpropyl]-Phe-p-aminobenzoate (cFP-F-pAB). cFP-AAF-pAB, cFP-A(D)AF-pAB and cFP-F-pAB produced equipotent dose-dependent (25-250 nmol) and time-dependent (5-7 h) antinociception with larger effects on the jump (49-51% increase) relative to the tail-flick (28-41% increase) test.
Gene_expression (produced) of cFP in tail associated with antinociception, tail-flick and intracerebroventricular
2) Confidence 0.65 Published 1991 Journal Int. J. Neurosci. Section Abstract Doc Link 1938129 Disease Relevance 0 Pain Relevance 0.74
The present study evaluated two inhibitors of endopeptidase 24.15, N-[1-(RS)-carboxy-3-phenyl-propyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB), and N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-D-Ala-Phe-p-aminobenzoate (cFP-A(D)AF-pAB), for antinociception on the tail-flick and jump tests in rats following intracerebroventricular administration relative to an inhibitor of endopeptidase 24.11, N-(1-(RS)-carboxy-3-phenylpropyl]-Phe-p-aminobenzoate (cFP-F-pAB). cFP-AAF-pAB, cFP-A(D)AF-pAB and cFP-F-pAB produced equipotent dose-dependent (25-250 nmol) and time-dependent (5-7 h) antinociception with larger effects on the jump (49-51% increase) relative to the tail-flick (28-41% increase) test.
Gene_expression (produced) of cFP in tail associated with antinociception, tail-flick and intracerebroventricular
3) Confidence 0.65 Published 1991 Journal Int. J. Neurosci. Section Abstract Doc Link 1938129 Disease Relevance 0 Pain Relevance 0.74
N-[1(R,S)-Carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB) is a potent, substrate-related, specific inhibitor of endopeptidase 24.15, an enzyme involved in the metabolism of bioactive peptides including bradykinin, neurotensin, and proenkephalin, and prodynorphin-derived enkephalin precursors.
Gene_expression (precursors) of cFP associated with enkephalin and bradykinin
4) Confidence 0.65 Published 1993 Journal Peptides Section Abstract Doc Link 8134308 Disease Relevance 0.25 Pain Relevance 0.15
All NA-PFC pairs tested (n?
Gene_expression (pairs) of NA-PFC associated with nucleus accumbens
5) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.38
Perseveration is a common observation in frontal lobe deficits and certain disorders that affect the PFC, such as schizophrenia [40].
Gene_expression (affect) of PFC in lobe associated with schizophrenia
6) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0.29 Pain Relevance 0.20
During the instrumental behavior component, the NA core, but not the shell, became synchronized with the PFC.
Gene_expression (synchronized) of PFC in shell associated with nucleus accumbens
7) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.19
For NA-PFC pairs, this ratio was 1.33±0.36 during the exploratory stage and increased to 1.67±0.40 during bar press (n?
Gene_expression (pairs) of NA-PFC in bar associated with nucleus accumbens
8) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.40
As the PFC-NA and VH-NA connections are not reciprocal (both areas send heavy monosynaptic projections to the NA), the coherence data suggest that NA core follows VH activity during spatial exploration, but follows PFC activity during an operant task, even in the presence of similar spatial information.
Neg (not) Gene_expression (reciprocal) of PFC-NA associated with nucleus accumbens and hippocampus
9) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663037 Disease Relevance 0 Pain Relevance 0.89
All patients had the PFC procedure performed successfully.
Gene_expression (procedure) of PFC
10) Confidence 0.56 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710379 Disease Relevance 0.70 Pain Relevance 0.19
We investigated the absolute concentration of N-acetylaspartate (NAA) in the anterior cingulated cortex (ACC), and prefrontal cortex (PFC) in chronic pain patients by proton magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects.
Gene_expression (prefrontal) of PFC in thalamus associated with lasting pain, thalamus and anterior cingulate
11) Confidence 0.56 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411706 Disease Relevance 0.27 Pain Relevance 0.56
In this model, the orbital PFC can be seen as the area where reward-related information is encoded (as discussed in “Introduction”) and the mPFC functions as an area that regulates or signals the orbital PFC to implement performance adjustments (based on reward information).
Gene_expression (functions) of mPFC
12) Confidence 0.55 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
Bilateral stainless steel cannulas (outside diameter 0.3 mm), connected to a microinfusion pump (801 syringe pump, Univentor, High Precision Engineering, Zejtun, Malta) with flexible PEEK tubing (0.51 mm outside diameter, 0.013 mm inside diameter; Aurora-Borealis, Schoonebeek, The Netherlands), were then placed in the mPFC at an angle of 12°, anterioposterior +30, lateral ±16; ventral ?
Gene_expression (placed) of mPFC in lateral
13) Confidence 0.55 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0.23 Pain Relevance 0.18
In this model, the orbital PFC can be seen as the area where reward-related information is encoded (as discussed in “Introduction”) and the mPFC functions as an area that regulates or signals the orbital PFC to implement performance adjustments (based on reward information).
Gene_expression (functions) of PFC
14) Confidence 0.55 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
We recently demonstrated that systemic administration of PCP to rats produces long-lasting activation of medial prefrontal cortex (mPFC) neurons with augmentation of locomotor activity, whereas direct application of PCP to mPFC neurons has little effect on their firing activity.
Gene_expression (produces) of mPFC in neurons associated with eae
15) Confidence 0.51 Published 2005 Journal Cereb. Cortex Section Abstract Doc Link 15342431 Disease Relevance 0.19 Pain Relevance 0.14
Finally, the down-regulation of both the number of D(1)-dopamine receptors and of the coupled adenylyl cyclase activity in the pre-frontal cortex (PFC) produced by long-term SKF 38393 administration was reverted by the superimposed morphine sensitization.
Gene_expression (produced) of PFC in frontal cortex associated with dopamine receptor, urological neuroanatomy and morphine
16) Confidence 0.49 Published 2000 Journal Brain Res. Section Abstract Doc Link 10640626 Disease Relevance 0.38 Pain Relevance 0.68
Fos expression in the PFC after HFS or LFS
Gene_expression (expression) of PFC associated with li-fraumeni syndrome
17) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2936438 Disease Relevance 0.69 Pain Relevance 0.03
Stimulation of PFC produced by 1 microgram/kg of Met-Enk was completely blocked with 10 and 50 micrograms/kg of ICI 174864.
Gene_expression (produced) of PFC
18) Confidence 0.41 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834369 Disease Relevance 0.43 Pain Relevance 0.59
The synapses of hippocampal fibers in the PFC can express different forms of plasticity.
Gene_expression (express) of PFC in synapses
19) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2936438 Disease Relevance 0.57 Pain Relevance 1.13
In our experiments, HFS delivered to HP/SB induced heterosynaptic potentiation in HP-PFC pathways (reflecting LTP of field potentials) and peripheral-PFC sensory pathways (plasticity of nociceptive responses).
Gene_expression (reflecting) of HP-PFC associated with nociception, long-term potentiation and hippocampus
20) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2936438 Disease Relevance 0.71 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox