INT177387

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.44
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF2) signal transduction (TRAF2) enzyme binding (TRAF2)
protein complex assembly (TRAF2) ligase activity (TRAF2) cytoplasm (TRAF2)
Anatomy Link Frequency
blood 1
leukocyte 1
TRAF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 50 99.02 Very High Very High Very High
cINOD 20 85.64 High High
Inflammation 11 32.40 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 408 77.36 Quite High
INFLAMMATION 15 75.68 Quite High
Repression 12 66.16 Quite High
Infection 78 53.36 Quite High
Cancer 24 14.28 Low Low
Death 18 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Retinoblastoma 9 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Shigella Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRAF2 is important for caspase-8 activation and is induced by NF-?
Positive_regulation (induced) of TRAF2
1) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.45 Pain Relevance 0
TRAF2 is important for caspase-8 activation and is induced by NF-?
Positive_regulation (important) of TRAF2
2) Confidence 0.19 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.43 Pain Relevance 0
Interestingly, TRAF2 was induced in WTSTS, and this induction was not seen in the U versus WT comparison.
Positive_regulation (induced) of TRAF2
3) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.42 Pain Relevance 0
Whole blood was incubated with three different concentrations of diclofenac and metamizol for 5 and 30 minutes, followed by activation with TRAP-6 and ADP.
Positive_regulation (activation) of TRAP-6 in blood associated with diclofenac
4) Confidence 0.01 Published 2004 Journal BMC Anesthesiol Section Abstract Doc Link PMC411036 Disease Relevance 0.08 Pain Relevance 0.43
There were no significant differences in the expression of GPIIb/IIIa and P-selectin, and in the formation of platelet-leukocyte complexes after activation with ADP and TRAP-6, regarding both the time of incubation and the concentrations of diclofenac and metamizol.


Positive_regulation (activation) of TRAP-6 in leukocyte associated with diclofenac
5) Confidence 0.01 Published 2004 Journal BMC Anesthesiol Section Abstract Doc Link PMC411036 Disease Relevance 0.06 Pain Relevance 0.41

General Comments

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