INT17739

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 32
Speculated 2
Reported most in Body
Documents 226
Total Number 228
Disease Relevance 132.70
Pain Relevance 26.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
neuron 17
brain 12
smooth muscle 8
astrocytes 5
blood 5
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 22 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
antidepressant 1125 99.84 Very High Very High Very High
depression 353 99.80 Very High Very High Very High
Nerve growth factor 440 99.78 Very High Very High Very High
anesthesia 95 99.76 Very High Very High Very High
Serotonin 13 99.56 Very High Very High Very High
cva 52 99.08 Very High Very High Very High
rheumatoid arthritis 186 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Carcinoma 86 100.00 Very High Very High Very High
Lymphatic System Cancer 68 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 44 100.00 Very High Very High Very High
Adhesions 20 100.00 Very High Very High Very High
Natriuresis 11 100.00 Very High Very High Very High
Neuromyelitis Optica 70 99.98 Very High Very High Very High
Melanoma 199 99.96 Very High Very High Very High
Bone Cancer 13 99.96 Very High Very High Very High
Cancer 1018 99.90 Very High Very High Very High
Obesity 918 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We analyzed the relationship between this tooth injury and the S100B expression in the trigeminal subnucleus caudalis.
Gene_expression (expression) of S100B in tooth associated with tooth injuries
1) Confidence 0.78 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20043976 Disease Relevance 0.44 Pain Relevance 0.26
Moreover our data show that the levels of S100B in the first three days are higher than that found by Gazzolo et al [14], in the colostrums of Caucasian women, collected an different time (starting 24 h after delivery).
Gene_expression (levels) of S100B in colostrums
2) Confidence 0.78 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.30 Pain Relevance 0.30
By immunohistochemical staining, we found that the focal areas expressed S-100 protein and HMB-45 antibody.
Gene_expression (expressed) of S-100 protein
3) Confidence 0.78 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10228810 Disease Relevance 1.02 Pain Relevance 0.07
While the results we present may be disappointing for the bench researcher, we also demonstrated that the clinical detection of S100B is more reproducible and robust.
Gene_expression (detection) of S100B
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.20 Pain Relevance 0
Similarly, Western blot measurements revealed that brain tissue expressed high levels of S100B but comparable levels were found in skeletal muscle.
Gene_expression (expressed) of S100B in brain
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.66 Pain Relevance 0.03
Although discussion of the possibilities of why we observed such varying expressions of S100B protein between the platforms of Western blot and ELISA is a very noteworthy, adequate analysis is beyond the scope of this paper.
Gene_expression (expressions) of S100B protein
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0 Pain Relevance 0
By ELISA, brain tissue expressed the highest S100B levels.
Gene_expression (expressed) of S100B in brain
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.60 Pain Relevance 0.03
However, it is also known that S100B may be detected in its monomeric or dimeric form.
Gene_expression (detected) of S100B
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.17 Pain Relevance 0.15
We confirm that S100B was not exclusively produced by CNS cells.
Neg (not) Gene_expression (produced) of S100B
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.21 Pain Relevance 0
An added standard of S100B was used to quantify S100B expression in tissues.
Gene_expression (expression) of S100B
10) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0 Pain Relevance 0
In our study, we directly measured the tissue specific expression of S100B in addition to serum S100B, which represents a collective source from multiple disease processes.
Gene_expression (expression) of S100B associated with disease
11) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 1.20 Pain Relevance 0.04
Analysis of human tissues by ELISA and Western blot revealed variable levels of S100B expression.
Gene_expression (expression) of S100B
12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.55 Pain Relevance 0.03
We found different levels of S100B expression by using two different antibodies and found poor qualitative and quantitative correlation.
Gene_expression (expression) of S100B
13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.13 Pain Relevance 0
The appearance of S100B protein followed the same pattern in all patients with high levels at the end of CPB and a decrease or slight increase the first hour (figure 2).
Gene_expression (appearance) of S100B protein
14) Confidence 0.78 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.09 Pain Relevance 0
One major reason for this could be the fact that S100B is present in high concentrations in shed mediastinal blood that is retransfused to the patient by cardiotomy suction and autotransfusion, thus obscuring the measured levels of S100B early after surgery.
Gene_expression (present) of S100B in blood
15) Confidence 0.78 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.33 Pain Relevance 0
There was a direct relationship between the expression of S100 beta and the level of 5-HT in the hippocampal formation.
Gene_expression (expression) of S100 beta in hippocampal formation
16) Confidence 0.76 Published 1993 Journal Brain Res. Section Abstract Doc Link 8298984 Disease Relevance 0 Pain Relevance 0.16
Hippocampal serotonin levels influence the expression of S100 beta detected by immunocytochemistry.
Gene_expression (expression) of S100 beta associated with serotonin
17) Confidence 0.76 Published 1993 Journal Brain Res. Section Title Doc Link 8298984 Disease Relevance 0 Pain Relevance 0.17
Of special interest is that all of the cases showed CD56 expression on the tumor cells in addition to expression of CD1a, S100beta, and langerin, the presence of which suggests derivation from Langerhans cells.
Gene_expression (expression) of S100beta in Langerhans cells associated with cancer
18) Confidence 0.75 Published 2005 Journal Int. J. Hematol. Section Abstract Doc Link 15914364 Disease Relevance 1.16 Pain Relevance 0.08
Low-molecular-weight cytokeratins, cytokeratin 20, vimentin, S100, p63, estrogen receptor, progesterone receptor, p53 and c-erbB-2 were negative in tumoral cells.
Neg (negative) Gene_expression (negative) of S100
19) Confidence 0.75 Published 2003 Journal Virchows Arch. Section Abstract Doc Link 12836022 Disease Relevance 1.10 Pain Relevance 0.07
The tumor cells expressed immunoreactivity for cytokeratin (AE1/AE3) and S-100.
Gene_expression (expressed) of S-100 associated with cancer
20) Confidence 0.75 Published 2009 Journal Indian J Pathol Microbiol Section Abstract Doc Link 19136797 Disease Relevance 0.66 Pain Relevance 0.08

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