INT177392

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.14
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) signal transduction (Npy1r) plasma membrane (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
hypothalamus 1
Npy1r (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 41 96.64 Very High Very High Very High
gABA 28 94.08 High High
Neuropeptide 20 92.52 High High
Central nervous system 21 90.68 High High
amygdala 7 87.92 High High
cerebral cortex 4 85.80 High High
Pyramidal cell 17 82.24 Quite High
agonist 55 72.16 Quite High
Dopamine 18 69.96 Quite High
antagonist 38 65.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 5 98.86 Very High Very High Very High
Cognitive Disorder 1 93.92 High High
Bordatella Infection 4 92.08 High High
Anxiety Disorder 2 89.32 High High
Autism 50 86.80 High High
Urological Neuroanatomy 2 83.84 Quite High
Neurodegenerative Disease 6 64.48 Quite High
Disease 15 57.32 Quite High
Parkinson's Disease 2 34.64 Quite Low
Hypoxia 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Receptor-receptor interactions between Y1Rs have already been described, such as the antagonistic interaction with galanin receptors in the hypothalamus of the rat and their functional relevance for food intake.
Y1R Binding (interactions) of in hypothalamus
1) Confidence 0.47 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.31 Pain Relevance 0.33
This is evidence for potential interaction between A1Rs and Y1Rs that may modulate long-term desensitization of A1Rs during pathophysiological situations.
Y1R Binding (interaction) of
2) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.22 Pain Relevance 0.24
Thorsell et al. [33] reported impaired spatial learning in transgenic rats that over expressed NPY and demonstrated decreased NPY Y1 receptor binding.
NPY Y1 receptor Binding (binding) of associated with targeted disruption
3) Confidence 0.32 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.61 Pain Relevance 0.41

General Comments

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