INT177394

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 100.00 Very High Very High Very High
Neuropeptide 10 99.24 Very High Very High Very High
Kinase C 18 92.32 High High
Hyperalgesia 4 82.12 Quite High
Inflammation 9 81.60 Quite High
spinal dorsal horn 7 74.48 Quite High
IPN 9 56.68 Quite High
Neuropathic pain 4 43.00 Quite Low
Glutamate receptor 24 33.96 Quite Low
nMDA receptor 4 32.56 Quite Low
Disease Link Frequency Relevance Heat
Autism 50 99.26 Very High Very High Very High
Nociception 26 86.76 High High
Hyperalgesia 5 82.12 Quite High
INFLAMMATION 9 81.60 Quite High
Chromosome Aberrations 1 78.00 Quite High
Inflammatory Pain 9 56.68 Quite High
Neuropathic Pain 4 43.00 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Intellectual Impairment 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R

Background

Positive_regulation (leading) of AMPA 2 Binding (hemizygosity) of associated with neurotransmitter, autism and neuropeptide
1) Confidence 0.45 Published 2004 Journal BMC Med Genet Section Title Doc Link PMC411038 Disease Relevance 0.73 Pain Relevance 0.10
On one hand, PICK1 can dimerise and the dimers may induce the aggregation of AMPA receptors in heterologous expression systems [44].
Spec (may) Positive_regulation (induce) of AMPA Binding (aggregation) of
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.26

General Comments

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