INT17742

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Context Info
Confidence 0.80
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 44
Total Number 44
Disease Relevance 17.14
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
brain 10
plasma 3
neutrophils 3
neuronal 2
neurons 2
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 135 99.64 Very High Very High Very High
Inflammation 73 99.62 Very High Very High Very High
bDMF 15 99.24 Very High Very High Very High
agonist 224 98.50 Very High Very High Very High
headache 5 96.68 Very High Very High Very High
chemokine 3 95.60 Very High Very High Very High
Serotonin 3 92.56 High High
Pain 26 91.92 High High
methadone 2 90.64 High High
depression 42 88.44 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 9 100.00 Very High Very High Very High
Renal Failure 11 99.64 Very High Very High Very High
Injury 58 99.60 Very High Very High Very High
Brain Injury 78 99.56 Very High Very High Very High
Cancer 14 99.52 Very High Very High Very High
Hypoxia 10 99.44 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.08 Very High Very High Very High
Obesity 178 98.44 Very High Very High Very High
Neurodegenerative Disease 22 98.32 Very High Very High Very High
Inflammatory Bowel Disease 15 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After delivery, when the lactation starts, S100B is secreted in human milk at a level 80–100 times that in mother plasma, but the function of S100B content in colostrums is still unknown [14].
Localization (secreted) of S100B in plasma
1) Confidence 0.80 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.14 Pain Relevance 0
S100B is released in relatively large amounts into both the maternal and foetal circulation during labour and a correlation between S100B in cord blood levels and the physiological events related to brain maturation has been documented [10-12].
Localization (released) of S100B in brain
2) Confidence 0.80 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.14 Pain Relevance 0.04
In other words, these results demonstrated that the main species of S100B released by the brain when the blood-brain barrier is disrupted is the S100 B-B.
Localization (released) of S100B in brain
3) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.11 Pain Relevance 0.04
Therefore, if release of S100B is due to a pathology initiating active synthesis rather than by passive release from necrotic astroglial cells (as in stroke) quantitative RT-PCR of S100B messenger RNA would be appropriate to further support any observations; 2) Antibody-independent methods such as MS should be included for validation of target recognition; 3) When possible HPLC (high-performance liquid chromatography) should be used in parallel or serial experiments.


Localization (release) of S100B associated with stroke
4) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.40 Pain Relevance 0
Although the majority of the literature using NIRS has compared periods of cerebral desaturation with outcome assessed by clinical assessment of neurologic status, Plachky et al. compared changes in cerebral oxygenation using NIRS monitoring with neurologic damage assessed with biochemical markers, including neuron specific enolase (NSE) and S-100, a protein released during neuronal damage.[19] The cohort for the study included 16 adult patients undergoing orthotopic hepatic transplantation.
Localization (released) of S-100 in neuronal
5) Confidence 0.78 Published 2006 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2997275 Disease Relevance 0.27 Pain Relevance 0.08
Because 5-HT induces release of S100beta, we investigated the codependence of 5-HT receptors and SERT in regulating S100A4/Mts1 in human pulmonary artery smooth muscle cells (hPA-SMC). 5-HT elevated S100A4/Mts1 mRNA levels and increased S100A4/Mts1 protein in hPA-SMC lysates and culture media.
Localization (release) of S100beta in artery smooth muscle
6) Confidence 0.78 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16002749 Disease Relevance 0.36 Pain Relevance 0.25
Longer-lasting treatment with NO liberator SNP seemed to decrease the release of S-100beta into the blood stream and may have delayed protection on the astroglial cells.
Localization (release) of S-100beta in blood
7) Confidence 0.78 Published 2000 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 11156353 Disease Relevance 0.06 Pain Relevance 0.06
Cytoplasm granules are typically seen under light microscopy, and the cells are positive for S100 immunoperoxidase and neuron-specific enolase.
Localization (immunoperoxidase) of S100 in neuron
8) Confidence 0.73 Published 2008 Journal Brazilian journal of otorhinolaryngology Section Abstract Doc Link 19082363 Disease Relevance 1.36 Pain Relevance 0.09
In contrast, hypoxia did not alter the cerebral exchange of S100beta and both global cerebral oxidative metabolism (cerebral metabolic rate of oxygen) and neuronal integrity (NSE) were preserved (P > 0.05 vs. normoxia).
Localization (exchange) of S100beta in neuronal associated with hypoxia
9) Confidence 0.73 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19726713 Disease Relevance 1.23 Pain Relevance 0.25
After delivery, when the lactation starts, S100B is secreted in human milk at a level 80–100 times that in mother plasma, but the function of S100B content in colostrums is still unknown [14].
Localization (secreted) of S100B in plasma
10) Confidence 0.71 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0.14 Pain Relevance 0
Western blot analysis revealed that, regardless of the antibody used, S100B is found in tissues other than brain.
Localization (found) of S100B in brain
11) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0 Pain Relevance 0
Western blot analysis revealed that, regardless of the antibody used, S100B is found in tissues other than brain.
Localization (found) of S100B in brain
12) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0.24 Pain Relevance 0
The main species of S100B released from the brain was the B-B homodimer.
Localization (released) of S100B in brain
13) Confidence 0.71 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937027 Disease Relevance 0.61 Pain Relevance 0
However, the aim of this study was to clarify the complex kinetics of early S100B release and its possible connection to a neuropsychological decline, not to determine the perfect use of S100b for detecting neuropsychological outcome after cardiac surgery.
Localization (release) of S100B
14) Confidence 0.70 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0 Pain Relevance 0
The univariate analysis did not provide a clear answer to the question whether there is a relationship between neuropsychological outcome and S100B release.
Localization (release) of S100B
15) Confidence 0.70 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0 Pain Relevance 0
There is a clear relation between patient age and release of S100B up to 24 hours after cardiac surgery.
Localization (release) of S100B
16) Confidence 0.70 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0 Pain Relevance 0
The controversial significance of an increased S100B immediately after surgery is indeed intriguing and it inspires further studies of the mechanisms of S100B release after cardiac surgery as well as other fields of brain damage.


Localization (release) of S100B in brain
17) Confidence 0.70 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.07 Pain Relevance 0
S100B is a low-molecular weight, calcium-binding protein secreted by glial and Schwann cells.
Localization (secreted) of S100B in Schwann cells
18) Confidence 0.70 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.32 Pain Relevance 0.22
S100B is released following brain injury of various aetiology.
Localization (released) of S100B in brain associated with brain injury
19) Confidence 0.70 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.30 Pain Relevance 0.21
The direct release of phagocyte-derived S100 proteins from inflamed tissues may reflect secretion from infiltrating neutrophils (S100A12) and also monocytes or epithelial cells (MRP8/14).
Localization (secretion) of S100 in neutrophils
20) Confidence 0.68 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.81 Pain Relevance 0.37

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