INT177434

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.52
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
crescent 1
IGAN (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 33 81.32 Quite High
cINOD 6 70.40 Quite High
Inflammation 3 68.40 Quite High
Pain 3 34.24 Quite Low
abdominal pain 3 17.04 Low Low
withdrawal 3 5.00 Very Low Very Low Very Low
peptic ulcer disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 108 100.00 Very High Very High Very High
Chronic Renal Failure 27 99.92 Very High Very High Very High
Proteinuria 54 97.30 Very High Very High Very High
Disorders Of Creatine Metabolism 3 91.96 High High
Renal Failure 69 83.20 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 77.12 Quite High
INFLAMMATION 3 68.40 Quite High
Herpes Zoster 9 51.16 Quite High
Mycobacterial Infection 3 44.36 Quite Low
Diabetes Mellitus 6 36.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgAN – IgA nephropathy
Gene_expression (nephropathy) of IgAN associated with renal disease
1) Confidence 0.42 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0.58 Pain Relevance 0.22
Criteria for inclusion in the study are: 1) patient age above 7 and less than 70 years, 2) renal biopsy diagnostic for IgAN based on immunohistologic staining for IgA that is greater than or equal to staining for IgG and IgM after the biopsy report has be evaluated by one of the study pathologists (entry into the study does not depend upon any specific time interval between the time of the renal biopsy and the time of entry), 3) ability to swallow the oral medications used in the study, 4) signed informed consent by subjects ?
Gene_expression (biopsy) of IgAN
2) Confidence 0.42 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0 Pain Relevance 0
Criteria for inclusion in the study are: 1) patient age above 7 and less than 70 years, 2) renal biopsy diagnostic for IgAN based on immunohistologic staining for IgA that is greater than or equal to staining for IgG and IgM after the biopsy report has be evaluated by one of the study pathologists (entry into the study does not depend upon any specific time interval between the time of the renal biopsy and the time of entry), 3) ability to swallow the oral medications used in the study, 4) signed informed consent by subjects ?
Gene_expression (based) of IgAN
3) Confidence 0.42 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0 Pain Relevance 0
Since the amount of proteinuria has been reported to be one of the most important prognosticators in IgAN [21–25] and the effect of steroid therapy on preventing the progression of IgAN is believed to link closely to reduction in urinary protein [14,26], we speculated that a low-dose PSL protocol was insufficient for the treatment of IgAN with moderate histological severity.
Gene_expression (progression) of IgAN associated with renal disease and proteinuria
4) Confidence 0.39 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2639065 Disease Relevance 1.01 Pain Relevance 0
They suggested that mPSL pulse therapy prevents the progression of IgAN through suppression of new crescent formation as well as transformation of cellular crescent to fibrocellular or fibrous crescent.
Gene_expression (progression) of IgAN in crescent associated with renal disease
5) Confidence 0.39 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2639065 Disease Relevance 0.62 Pain Relevance 0
The protective effect of mPSL pulse therapy against the progression of IgAN was demonstrated as level-one evidence by their control trial.
Gene_expression (progression) of IgAN associated with renal disease
6) Confidence 0.39 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2639065 Disease Relevance 0.32 Pain Relevance 0

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