INT177448

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cbl) nucleus (Cbl) ligase activity (Cbl)
cytoplasm (Cbl) signal transducer activity (Cbl)
Anatomy Link Frequency
osteoclasts 1
Cbl (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 40 77.36 Quite High
cytokine 18 65.00 Quite High
Inflammation 19 51.92 Quite High
rheumatoid arthritis 36 46.00 Quite Low
member 8 2 13.48 Low Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 2 99.24 Very High Very High Very High
Arthritis 46 90.00 High High
INFLAMMATION 18 51.92 Quite High
Disease 12 49.76 Quite Low
Rheumatoid Arthritis 36 46.00 Quite Low
Apoptosis 6 21.60 Low Low
Death 1 9.12 Low Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Src tyrosine kinase function (and two of its targets, Ras and Cbl) are required for bone resorption by osteoclasts [28-30].
Regulation (targets) of Cbl in osteoclasts associated with hypercalcemia
1) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.37 Pain Relevance 0.12
In this paper, we describe the selective expression patterns in taste tissues and the novel molecular properties of Lrmp/Jaw1 and discuss its possible role as a candidate regulator of IP3-Ca2+ signal cascade in sweet, bitter, and umami taste signal transduction.


Spec (possible) Regulation (regulator) of signal transduction
2) Confidence 0.01 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

General Comments

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