INT177448

Context Info Confidence 0.12 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.37 Pain Relevance 0.12

plasma membrane (Cbl) nucleus (Cbl) ligase activity (Cbl) cytoplasm (Cbl) signal transducer activity (Cbl)

Anatomy Link Frequency osteoclasts 1 Cbl (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 40 77.36 cytokine 18 65.00 Inflammation 19 51.92 rheumatoid arthritis 36 46.00 member 8 2 13.48 Osteoarthritis 11 5.00 Inflammatory response 2 5.00 antagonist 2 5.00 anesthesia 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 2 99.24 Arthritis 46 90.00 INFLAMMATION 18 51.92 Disease 12 49.76 Rheumatoid Arthritis 36 46.00 Apoptosis 6 21.60 Death 1 9.12 Osteoarthritis 11 5.00 Pressure And Volume Under Development 7 5.00 Necrosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Src tyrosine kinase function (and two of its targets, Ras and Cbl) are required for bone resorption by osteoclasts [28-30].

Regulation (targets) of Cbl in osteoclasts associated with hypercalcemia

1) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.37 Pain Relevance 0.12

In this paper, we describe the selective expression patterns in taste tissues and the novel molecular properties of Lrmp/Jaw1 and discuss its possible role as a candidate regulator of IP3-Ca2+ signal cascade in sweet, bitter, and umami taste signal transduction.

Spec (possible) Regulation (regulator) of signal transduction

2) Confidence 0.01 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

General Comments

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